Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial

被引：203

作者：

Brasky, Theodore M. ^{[1
,2
]}

Darke, Amy K. ^{[3
]}

Song, Xiaoling ^{[2
]}

Tangen, Catherine M. ^{[3
]}

Goodman, Phyllis J. ^{[3
]}

Thompson, Ian M. ^{[4
]}

Meyskens, Frank L., Jr. ^{[5
]}

Goodman, Gary E. ^{[2
,6
]}

Minasian, Lori M. ^{[8
]}

Parnes, Howard L. ^{[8
]}

Klein, Eric A. ^{[9
]}

Kristal, Alan R. ^{[2
,7
]}

机构：

[1] Ohio State Univ, Coll Med, Dept Internal Med, Div Canc Prevent & Control, Columbus, OH 43201 USA

[2] Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98104 USA

[3] Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98104 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Urol, San Antonio, TX 78229 USA

[5] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA USA

[6] Univ Washington, Dept Environm Hlth, Seattle, WA 98195 USA

[7] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[8] NCI, Canc Prevent Div, NIH, Bethesda, MD 20892 USA

[9] Cleveland Clin, Glickman Urol & Kidney Inst, Cleveland, OH 44106 USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2013年 / 105卷 / 15期

关键词：

PREVENTION TRIAL; VITAMIN-E; DIETARY/SUPPLEMENTAL OMEGA-3-FATTY-ACIDS; DIETARY-SUPPLEMENTS; GENERAL HEALTH; SELENIUM; BLOOD; OMEGA-3; DISEASE;

D O I：

10.1093/jnci/djt174

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Studies of dietary ?-3 fatty acid intake and prostate cancer risk are inconsistent; however, recent large prospective studies have found increased risk of prostate cancer among men with high blood concentrations of long-chain ?-3 polyunsaturated fatty acids ([LC?-3PUFA] 20:5?3; 22:5?3; 22:6?3]. This casecohort study examines associations between plasma phospholipid fatty acids and prostate cancer risk among participants in the Selenium and Vitamin E Cancer Prevention Trial. Case subjects were 834 men diagnosed with prostate cancer, of which 156 had high-grade cancer. The subcohort consisted of 1393 men selected randomly at baseline and from within strata frequency matched to case subjects on age and race. Proportional hazards models estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations between fatty acids and prostate cancer risk overall and by grade. All statistical tests were two-sided. Compared with men in the lowest quartiles of LC?-3PUFA, men in the highest quartile had increased risks for low-grade (HR 1.44, 95% CI 1.08 to 1.93), high-grade (HR 1.71, 95% CI 1.00 to 2.94), and total prostate cancer (HR 1.43, 95% CI 1.09 to 1.88). Associations were similar for individual long-chain ?-3 fatty acids. Higher linoleic acid (?-6) was associated with reduced risks of low-grade (HR 0.75, 95% CI 0.56 to 0.99) and total prostate cancer (HR 0.77, 95% CI 0.59 to 1.01); however, there was no dose response. This study confirms previous reports of increased prostate cancer risk among men with high blood concentrations of LC?-3PUFA. The consistency of these findings suggests that these fatty acids are involved in prostate tumorigenesis. Recommendations to increase LC?-3PUFA intake should consider its potential risks.

引用

页码：1132 / 1141

页数：10

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