Mediators of the allergic inflammation: Do they play a role in tissue fibrogenesis?

被引：0

作者：

Letuve, S. ^{[1
,2
]}

机构：

[1] Univ Paris Diderot, UMRS 700, Sorbonne Paris Cite, F-75018 Paris, France

[2] Univ Paris 07, INSERM, U700, F-75018 Paris, France

来源：

REVUE FRANCAISE D ALLERGOLOGIE | 2013年 / 53卷 / 08期

关键词：

Allergy; Fibrosis; Inflammation; Fibroblasts; Epithelium; Extracellular matrix; ACTIVATION-REGULATED CHEMOKINE; GROWTH-FACTOR; BASEMENT-MEMBRANE; SUBEPITHELIAL FIBROSIS; COLLAGEN PRODUCTION; IL-13; ASTHMA; EXPRESSION; PERIOSTIN; MECHANISMS;

D O I：

10.1016/j.reval.2013.10.002

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Subepithelial fibrogenesis is a component of tissue remodeling that is frequently observed in allergic diseases with mucosal involvement, such as asthma. The components of allergic inflammation, in particular Th2 cytokines and inflammatory cells, are able to favor tissue fibrosis by acting at different steps, either directly or through the promotion of fibrogenic Mediators, such as TGF-beta 1. Since the protective effect of corticosteroids on tissue fibrosis has not yet been clearly demonstrated, a better understanding of the contribution of the allergic reaction to this process appears necessary in order to identify new molecular targets aimed at preventing and/or reversing this phenomenon. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：628 / 634

页数：7

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