Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis

被引：198

作者：

Wu, Chih-Hsing ^{[1
,2
]}

Tu, Shih-Te ^{[3
]}

Chang, Yin-Fan ^{[1
]}

Chan, Ding-Cheng ^{[4
,5
,6
]}

Chien, Jui-Teng ^{[7
]}

Lin, Chih-Hsueh ^{[8
]}

Singh, Sonal ^{[9
]}

Dasari, Manikanta ^{[10
]}

Chen, Jung-Fu ^{[11
]}

Tsai, Keh-Sung ^{[12
]}

机构：

[1] Natl Cheng Kung Univ, Dept Family Med, Coll Med & Hosp, 138 Sheng Li Rd, Tainan 70428, Taiwan

[2] Natl Cheng Kung Univ, Inst Gerontol, Coll Med, 138 Sheng Li Rd, Tainan 70428, Taiwan

[3] Changhua Christian Hosp, LuKang Branch, 135 Nanhsiao St, Changhua 500, Taiwan

[4] Natl Taiwan Univ Hosp, Chu Tung Branch, 52 Jshan Rd, Hsinchu 31064, Hsinchu County, Taiwan

[5] Natl Taiwan Univ Hosp, Dept Geriatr & Gerontol, 7 Chung Shan S Rd, Taipei 10002, Taiwan

[6] Natl Taiwan Univ Hosp, Dept Internal Med, 1 Changde St, Taipei 10048, Taiwan

[7] Buddhist Dalin Tzuchi Hosp, 2 Min Sheng Rd, Dalin, Chiayi, Taiwan

[8] China Med Univ Hosp, Dept Family Med, 2 Yuh Der Rd, Taichung, Taiwan

[9] Univ Massachusetts, Med Sch, Dept Family Med & Community Hlth, Meyers Primary Care Inst, 55 Lake Ave North, Worcester, MA 01655 USA

[10] Complete HEOR Solut LLC, 1046 Knapp Rd, N Wales, PA 19454 USA

[11] Chang Gung Mem Hosp, Div Endocrinol & Metab, Dept Internal Med, 123 Ta Pei Rd, Kaohsiung, Taiwan

[12] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Zhong Shan South Rd, Taipei 10048, Taiwan

来源：

BONE | 2018年 / 111卷

关键词：

Osteoporosis; Fracture liaison services (FLS); Meta-analysis; Re-fracture; Outcomes; RISK;

D O I：

10.1016/j.bone.2018.03.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs. Methods: Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000-February 2017 inclusive) using the keywords 'osteoporosis', 'fractures', 'liaison', and 'service' to identify randomised controlled trials and observational studies of patients aged 50 years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS. Risk of bias was assessed at outcome level. Meta-analysis followed a random-effects and fixed-effects model. Outcomes of interest were incidence of bone mineral density (BMD) testing, treatment initiation, adherence, re-fractures, and mortality due to osteoporosis treatment. Results: A total of 159 publications were identified for the systematic literature review; 74 controlled studies (16 RCTs; 58 observational studies) were included in the meta-analysis. Overall, 41 of 58 observational studies and 12 of 16 RCI's were considered of high quality. Compared with patients receiving usual care (or those in the control arm), patients receiving care from an FLS program had higher rates of BMD testing (48.0% vs 23.5%) and treatment initiation (38.0% vs 17.2%) and greater adherence (57.0% vs 34.1%). Unweighted average rates of re-fracture were 13.4% among patients in the control arm and 6.4% in the FLS arm. Unweighted average rates of mortality were 15.8% in the control arm and 10.4% in the FLS arm. Meta-analysis revealed significant FLS-associated improvements in all outcomes versus non-FLS controls, with BMD testing increased by 24 percentage points (95% confidence interval [CI] 0.18-029), 20 percentage points for treatment rates (95% CI 0.16-0.25), and 22 percentage points for adherence (95% Cl 0.13-0.31) and absolute risk of re-fracture reduced by five percentage points (95% CI-0.08 to -0.03) and mortality reduced by three percentage points (95% CI -0.05 to -0.01). Conclusion: FLS programs improved outcomes of osteoporosis-related fractures, with significant increases in BMD testing, treatment initiation, and adherence to treatment and reductions in re-fracture incidence and mortality. (C) 2018 The Authors. Published by Elsevier Inc.

引用

页码：92 / 100

页数：9

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