Emerging Pandemic Diseases: How We Got to COVID-19

被引：446

作者：

Morens, David M. ^{[1
]}

Fauci, Anthony S. ^{[1
]}

机构：

[1] NIAID, Off Director, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

CELL | 2020年 / 182卷 / 05期

关键词：

ANTIBODY-MEDIATED ENHANCEMENT; FELINE INFECTIOUS PERITONITIS; SARS CORONAVIRUS; VIRUS; EMERGENCE; CHALLENGE; INFLUENZA; RECEPTOR; EPIDEMIOLOGY; PATHOGENESIS;

D O I：

10.1016/j.cell.2020.08.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Infectious diseases prevalent in humans and animals are caused by pathogens that once emerged from other animal hosts. In addition to these established infections, new infectious diseases periodically emerge. In extreme cases they may cause pandemics such as COVID-19; in other cases, dead-end infections or smaller epidemics result. Established diseases may also re-emerge, for example by extending geographically or by becoming more transmissible or more pathogenic. Disease emergence reflects dynamic balances and imbalances, within complex globally distributed ecosystems comprising humans, animals, pathogens, and the environment. Understanding these variables is a necessary step in controlling future devastating disease emergences.

引用

页码：1077 / 1092

页数：16

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