ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.

被引：184
|
作者：
Slominski, A
Ermak, G
Mihm, M
机构：
[1] Dept. of Pathol. and Lab. Medicine, Albany Medical College, Albany
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1996年 / 81卷 / 07期
关键词：
D O I：
10.1210/jc.81.7.2746
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Evidence is provided that mRNA for ACTH (MC-2) receptor and mRNAs for three obligatory enzymes of steroid synthesis including cytochromes P450scc, P450c17 and P450c21 are expressed in normal and pathologic human skin. Thus, molecular elements of the distal loop of the ''pituitary-adrenal axis'' such as the MC-2, CYP11A1, CYP17 and CYP21A2 genes are expressed in the skin.
引用
收藏
页码：2746 / 2749
页数：4
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