Glucagon-like peptide 1 modulates histaminergic action in the central regulation of food intake in rats

被引：0

作者：

Kurose, Y ^{[1
]}

Suzuki, A ^{[1
]}

Tamura, N ^{[1
]}

Tamura, M ^{[1
]}

Nakao, T ^{[1
]}

Noguchi, T ^{[1
]}

Hasemi, T ^{[1
]}

Terashima, Y ^{[1
]}

机构：

[1] Kitasato Univ, Fac Anim Sci, Dept Anim Nutr, Towada, Aomori 0348628, Japan

来源：

HISTAMINE RESEARCH IN THE NEW MILLENNIUM | 2001年 / 1224卷

关键词：

histamine; glucagon-like peptide 1; food intake; brain; microdialysis;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

We investigated whether central histamine is responsible for the reduction in food intake by GLP-1. The inhibitory effect of GLP-1 on eating was attenuated by histamine depletion and the blockade of histamine HI-receptors. These results suggests that activation of histamine H1-receptors may contribute to the inhibitory effect of GLP-1 on feeding. Histamine levels were unexpectedly decreased by GLP-1 infusion in the hypothalamus. The local injection of GLP-1 into the hypothalamus might cause feeding-stimulatory processes that reduce histamine release.

引用

页码：465 / 466

页数：2