A novel poxvirus lethal to red squirrels (Sciurus vulgaris)

被引:49
作者
Thomas, K
Tompkins, DM
Sainsbury, AW
Wood, AR
Dalziel, R
Nettleton, PF
McInnes, CJ [1 ]
机构
[1] Univ Stirling, Stirling FK9 4LA, Scotland
[2] Moredun Res Inst, Penicuik EH26 OPZ, Midlothian, Scotland
[3] Inst Zool, London, England
[4] Univ Edinburgh, Edinburgh, Midlothian, Scotland
关键词
D O I
10.1099/vir.0.19464-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A parapoxvirus has been implicated in the decline of the red squirrel in the United Kingdom. Virus was isolated from an outbreak of lethal disease in red squirrels in the north-east of England. Experimental infection of captive-bred red squirrels confirmed that this virus was the cause of the severe skin lesions observed. Electron microscopic examination of the virus showed that it had a morphology typical of parapoxviruses whilst preliminary sequence data suggested a genomic G + C composition of approximately 66%, again similar to that found in other parapoxviruses. However Southern hybridization analysis failed to detect three known parapoxvirus genes, two of which have been found so far only in the genus Parapoxvirus. Comparative sequence analysis of two other genes, conserved across the eight recognized chordopoxvirus genera, suggests that the squirrel virus represents a previously unrecognized genus of the Chordopoxviridae.
引用
收藏
页码:3337 / 3341
页数:5
相关论文
共 33 条
  • [1] IDENTIFICATION OF RPO30, A VACCINIA VIRUS-RNA POLYMERASE GENE WITH STRUCTURAL SIMILARITY TO A EUKARYOTIC TRANSCRIPTION ELONGATION-FACTOR
    AHN, BY
    GERSHON, PD
    JONES, EV
    MOSS, B
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (10) : 5433 - 5441
  • [2] Characterization of sealpox virus, a separate member of the parapoxviruses
    Becher, P
    König, M
    Müller, G
    Siebert, U
    Thiel, HJ
    [J]. ARCHIVES OF VIROLOGY, 2002, 147 (06) : 1133 - 1140
  • [3] Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2
    Deane, D
    McInnes, CJ
    Percival, A
    Wood, A
    Thomson, J
    Lear, A
    Gilray, J
    Fleming, S
    Mercer, A
    Haig, D
    [J]. JOURNAL OF VIROLOGY, 2000, 74 (03) : 1313 - 1320
  • [4] Duff JP, 1996, VET REC, V138, P527
  • [5] Edwards F. B., 1962, Veterinary Record, V74, P739
  • [6] FELSENSTEIN J, 1985, EVOLUTION, V39, P783, DOI 10.1111/j.1558-5646.1985.tb00420.x
  • [7] A homolog of interleukin-10 is encoded by the poxvirus orf virus
    Fleming, SB
    McCaughan, CA
    Andrews, AE
    Nash, AD
    Mercer, AA
    [J]. JOURNAL OF VIROLOGY, 1997, 71 (06) : 4857 - 4861
  • [8] A CRITICAL-LOOK AT CONSERVING THE BRITISH RED SQUIRREL SCIURUS-VULGARIS
    GURNELL, J
    PEPPER, H
    [J]. MAMMAL REVIEW, 1993, 23 (3-4) : 127 - 137
  • [9] The reactivity of monoclonal antibodies against orf virus with other parapoxviruses and the identification of a 39 kDa immunodominant protein
    Housawi, FMT
    Roberts, GM
    Gilray, JA
    Pow, I
    Reid, HW
    Nettleton, PF
    Sumption, KJ
    Hibma, MH
    Mercer, AA
    [J]. ARCHIVES OF VIROLOGY, 1998, 143 (12) : 2289 - 2303
  • [10] Detection and diagnosis of parapoxvirus by the polymerase chain reaction
    Inoshima, Y
    Morooka, A
    Sentsui, H
    [J]. JOURNAL OF VIROLOGICAL METHODS, 2000, 84 (02) : 201 - 208