Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications

被引：632

作者：

Alves, N. M. ^{[1
,2
]}

Mano, J. F. ^{[1
,2
]}

机构：

[1] Univ Minho, Headquarters European Inst Excellence Tissue Engn, Dept Polymer Engn, Res Grp Biomat Biodegradables & Biomimet 3Bs, P-4806909 Caldas Das Taipas, Guimaraes, Portugal

[2] Inst Biotechnol & Bioengn, Braga, Portugal

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2008年 / 43卷 / 05期

关键词：

Chitosan; Chitosan derivatives; Biomedical applications; Biomaterials; Polysaccharides;

D O I：

10.1016/j.ijbiomac.2008.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chitosan is a natural based polymer, obtained by alkaline deacetylation of chitin, which presents excellent biological properties such as biodegradability and immunological, antibacterial and wound-healing activity. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. The main chemical modifications of chitosan that have been proposed in the literature are reviewed in this paper. Moreover, these chemical modifications lead to a wide range of derivatives with a broad range of applications. Recent and relevant examples of the distinct applications, with particular emphasis on tissue engineering, drug delivery and environmental applications, are presented. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：401 / 414

页数：14

共 183 条

[1] Temperature-sensitive chitosan-poly(N-isopropylacrylamide) interpenetrated networks with enhanced loading capacity and controlled release properties [J].