Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa

被引：48
作者：
Ernst-Russell, MA
Elix, JA [1 ]
Chai, CLL
Willis, AC
Hamada, N
Nash, TH
机构：
[1] Australian Natl Univ, The Fac, Dept Chem, Canberra, ACT 0200, Australia
[2] Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia
[3] Osaka City Inst Publ Hlth & Environm Sci, Tennoji Ku, Osaka 543, Japan
[4] Arizona State Univ, Dept Bot, Tempe, AZ 85287 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 34期
关键词：
D O I：
10.1016/S0040-4039(99)01220-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC50 c 0.27 CIM), active against the murine P815 mastocytoma cell line. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：6321 / 6324
页数：4
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