Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ("Tree of Heaven")

被引：53

作者：

Hong, Zhi-Lai ^{[1
,2
,3
]}

Xiong, Juan ^{[1
]}

Wu, Shi-Biao ^{[2
,3
]}

Zhu, Jing-Jing ^{[2
,3
]}

Hong, Jun-Lin ^{[4
]}

Zhao, Yun ^{[2
,3
]}

Xia, Gang ^{[2
,3
]}

Hu, Jin-Feng ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 201203, Peoples R China

[2] E China Normal Univ, Dept Nat Prod Chem Genet Res, Key Lab Brain Funct Genom, Minist Educ, Shanghai 200062, Peoples R China

[3] E China Normal Univ, Shanghai Key Lab Brain Funct Genom, Shanghai 200062, Peoples R China

[4] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China

来源：

PHYTOCHEMISTRY | 2013年 / 86卷

关键词：

Ailanthus altissima; Simaroubaceae; Triterpenoids; Altissimanins; Atissimacoumarins; Cytotoxicities; CANCER-CELL LINES; TIRUCALLANE TRITERPENES; DAMMARANE TRITERPENES; SUNFLOWER POLLEN; STEM BARK; TERPENOIDS; CONFIGURATION; CONSTITUENTS; QUASSINOIDS; FRUITS;

D O I：

10.1016/j.phytochem.2012.10.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetracyclic triterpenoids (named as altissimanins A-E, 1-5) and a terpenylated coumarin (denominated as altissimacoumarin G, 6), along with fifteen known compounds (7-21) were isolated from the bark of Ailanthus altissima. Structures of compounds 1-6 were established by spectroscopic methods and chemical transformations. Altissimanin A (1) is a tirucallane-type triterpenoid bearing an uncommon oxetane ring in the side-chain, while altissimanins D (4) and E (5) are two unprecedented dimers each consisting of one tirucallane-type and one dammarane-type triterpenoid moiety. All the isolates were evaluated for their cytotoxic effects against a small panel of human cancer cell lines. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：159 / 167

页数：9

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