Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ("Tree of Heaven")

被引:53
作者
Hong, Zhi-Lai [1 ,2 ,3 ]
Xiong, Juan [1 ]
Wu, Shi-Biao [2 ,3 ]
Zhu, Jing-Jing [2 ,3 ]
Hong, Jun-Lin [4 ]
Zhao, Yun [2 ,3 ]
Xia, Gang [2 ,3 ]
Hu, Jin-Feng [1 ,2 ,3 ]
机构
[1] Fudan Univ, Dept Nat Prod Chem, Sch Pharm, Shanghai 201203, Peoples R China
[2] E China Normal Univ, Dept Nat Prod Chem Genet Res, Key Lab Brain Funct Genom, Minist Educ, Shanghai 200062, Peoples R China
[3] E China Normal Univ, Shanghai Key Lab Brain Funct Genom, Shanghai 200062, Peoples R China
[4] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China
关键词
Ailanthus altissima; Simaroubaceae; Triterpenoids; Altissimanins; Atissimacoumarins; Cytotoxicities; CANCER-CELL LINES; TIRUCALLANE TRITERPENES; DAMMARANE TRITERPENES; SUNFLOWER POLLEN; STEM BARK; TERPENOIDS; CONFIGURATION; CONSTITUENTS; QUASSINOIDS; FRUITS;
D O I
10.1016/j.phytochem.2012.10.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tetracyclic triterpenoids (named as altissimanins A-E, 1-5) and a terpenylated coumarin (denominated as altissimacoumarin G, 6), along with fifteen known compounds (7-21) were isolated from the bark of Ailanthus altissima. Structures of compounds 1-6 were established by spectroscopic methods and chemical transformations. Altissimanin A (1) is a tirucallane-type triterpenoid bearing an uncommon oxetane ring in the side-chain, while altissimanins D (4) and E (5) are two unprecedented dimers each consisting of one tirucallane-type and one dammarane-type triterpenoid moiety. All the isolates were evaluated for their cytotoxic effects against a small panel of human cancer cell lines. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:159 / 167
页数:9
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