Vasopressin(4-9) fragment activates V1a-type vasopressin receptor in rat supraoptic neurones

被引:5
作者
Gouzènes, L [1 ]
Dayanithi, G [1 ]
Moos, FC [1 ]
机构
[1] CNRS, UPR 9055, Ctr Pharmacol Endocrinol, F-34094 Montpellier 5, France
关键词
hypothalamus; intracellular calcium; magnocellular neurones; neuropeptides; proteolytic degradation; vasopressin receptor;
D O I
10.1097/00001756-199906030-00020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE effect of vasopressin fragment 4-9 (AVP((4-9))) was investigated on freshly dissociated rat supraoptic neurones by measuring changes in intracellular calcium concentration ([Ca2+](i)) using fura-2 microspectrofluorimetry. In 60% of neurones responding to vasopressin, AVP((4-9)) induced a transient rise in [Ca2+](i) that was dose-dependent in the concentration range 10 nM to 1 mu M AVP((4-9)) and strongly decreased in Ca2+-free buffer (84% inhibition). This [Ca2+](i) response was completely and reversibly abolished by SR 49059 (10 nM), a specific V-1a receptor antagonist, but not by SR 121463A, a specific V-2 receptor antagonist. Our results demonstrate the presence of functional receptors activated by AVP(4-9) On vasopressin-sensitive neurones that possess the apparent pharmacological profile of the V-1a-type vasopressin receptor. NeuroReport 10:1735-1739 (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码:1735 / 1739
页数:5
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