This study was conducted to evaluate the effects of cage density on laying hen performance, egg quality parameters, blood indices, and excreta mineral concentration. Eighty White Leghorns were housed at 4 cage densities of 2,000, 1,000, 667, and 500 cm(2) per hen, corresponding to 1, 2, 3, and 4 hens per cage. Throughout the study, hens were fed a diet containing 2,852 kcal of ME/kg and 18% CP from 35 to 47 wk of age. Hen-day egg production and egg quality parameters were recorded weekly. Blood plasma was also subjected to several biochemical tests. The hens in the treatment having 4 hens per cage had significantly lower (P < 0.05) BW, egg weight, hen-day egg production, egg mass, feed intake, egg surface area, unit surface eggshell weight, yolk color, plasma calcium, and plasma uric acid than hens in the treatment with 1 hen per cage. However, those hens had significantly higher (P < 0.05) FCR, egg specific gravity, eggshell ratio, plasma iron and magnesium, plasma glucose, and moisture content of excreta than hens in the treatment with 1 hen per cage. On the basis of these results, White Leghorn hens (Hy-Line W36) could be kept in cages at densities of 2,000 or 1,000 cm2 to improve egg quality parameters and performance.