COVID-19 and Fungal infections: a double debacle

被引：17

作者：

Mina, Sara ^{[1
]}

Yaakoub, Hajar ^{[2
]}

Annweiler, Cedric ^{[3
,4
,5
]}

Dubee, Vincent ^{[6
,7
]}

Papon, Nicolas ^{[2
]}

机构：

[1] Beirut Arab Univ, Fac Hlth Sci, Dept Med Lab Sci, Beirut, Lebanon

[2] Univ Angers, Univ Brest, IRF, SFR ICAT, F-49000 Angers, France

[3] Univ Hosp Angers, Dept Geriatr Med, Res Ctr Auton & Longev, Angers, France

[4] Univ Hosp Angers, Res Ctr Auton & Longev, Memory Clin, Angers, France

[5] Univ Nantes, Univ Angers, LPPL, SFR CONFLUENCES, F-49000 Angers, France

[6] Univ Nantes, Univ Angers, INSERM, CRCINA,INCIT,SFR ICAT, F-49000 Angers, France

[7] Angers Univ Hosp, Dept Infect Dis, Angers, France

来源：

MICROBES AND INFECTION | 2022年 / 24卷 / 08期

关键词：

Fungal infections; COVID-19; Aspergillus; Mucoromycetes; Pneumocystis; Candida; RESPIRATORY-DISTRESS-SYNDROME; DESORPTION IONIZATION-TIME; CRITICALLY-ILL PATIENTS; PULMONARY ASPERGILLOSIS; CORONAVIRUS DISEASE; PNEUMOCYSTIS JIROVECII; MUCORMYCOSIS; PREVALENCE; IDENTIFICATION; PATHOGENESIS;

D O I：

10.1016/j.micinf.2022.105039

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fungal infections remain hardly treatable because of unstandardized diagnostic tests, limited antifungal armamentarium, and more specifically, potential toxic interactions between antifungals and immuno-suppressants used during anti-inflammatory therapies, such as those set up in critically ill COVID-19 patients. Taking into account pre-existing difficulties in treating vulnerable COVID-19 patients, any co -occurrence of infectious diseases like fungal infections constitutes a double debacle for patients, healthcare experts, and the public economy. Since the first appearance of SARS-CoV-2, a significant rise in threatening fungal co-infections in COVID-19 patients has been testified in the scientific literature. Better management of fungal infections in COVID-19 patients is, therefore, a priority and requires highlighting common risk factors, relationships with immunosuppression, as well as challenges in fungal diagnosis and treatment. The present review attempts to highlight these aspects in the three most identified causative agents of fungal co-infections in COVID-19 patients: Aspergillus, Candida, and Mucorales species. (C) 2022 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页数：11

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