Targeting the B-Cell Lymphoma/Leukemia 2 Family in Cancer

被引：229
作者：
Davids, Matthew S. [1 ]
Letai, Anthony [1 ]
机构：
[1] Dana Farber Canc Inst, Boston, MA 02215 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 30卷 / 25期
关键词：
CHRONIC LYMPHOCYTIC-LEUKEMIA; BCL-2 ANTISENSE OLIGONUCLEOTIDE; ACUTE MYELOID-LEUKEMIA; BH3 MIMETIC ABT-737; PHASE-I; CHROMOSOME-TRANSLOCATION; MITOCHONDRIAL-MEMBRANE; OBLIMERSEN SODIUM; CYTOCHROME-C; OBATOCLAX MESYLATE;
D O I：
10.1200/JCO.2011.37.0981
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The B-cell lymphoma/leukemia 2 (BCL-2) family of proteins has attracted the attention of cancer biologists since the cloning of BCL-2 more than 25 years ago. In the intervening decades, the way the BCL-2 family controls commitment to programmed cell death has been greatly elucidated. Several drugs directed at inhibiting BCL-2 and related antiapoptotic proteins have been tested clinically, with some showing considerable promise, particularly in lymphoid malignancies. A better understanding of the BCL-2 family has also provided insight into how conventional chemotherapy selectively kills cancer cells and why some cancers are more chemosensitive than others. Further exploitation of our understanding of the BCL-2 family promises to offer improved predictive biomarkers for oncologists and improved therapies for patients with cancer. J Clin Oncol 30: 3127-3135. (C) 2012 by American Society of Clinical Oncology
引用
收藏
页码：3127 / 3135
页数：9
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