Phorone A and Isophorbasone A, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp.

被引：29
|
作者：
Wang, Weihong [2 ]
Lee, Yehee [2 ]
Lee, Tae Gu [2 ]
Mun, Bora [2 ]
Giri, Awadut G. [2 ]
Lee, Jihye [2 ]
Kim, Hiyoung [2 ]
Hahn, Dongyup [2 ]
Yang, Inho [2 ]
Chin, Jungwook [2 ,3 ]
Choi, Hyukjae [2 ]
Nam, Sang-Jip [1 ]
Kang, Heonjoong [2 ,3 ]
机构：
[1] Sunchon Natl Univ, Inst Life & Pharmaceut Sci, Coll Pharm & Res, Sunchon 540950, South Korea
[2] Seoul Natl Univ, Ctr Marine Nat Prod & Drug Discovery, Sch Earth & Environm Sci, Seoul 151747, South Korea
[3] Seoul Natl Univ, Res Inst Oceanog, Seoul 151747, South Korea
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 17期
关键词：
STRUCTURE ELUCIDATION; A-D; G-I; DITERPENES; AMARANTHUS; CONFIGURATIONS; PHORBOXAZOLE; GUKULENSIS; MACROLIDES; CD;
D O I：
10.1021/ol3019874
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new "phorane" (5) and "isophorbasane' (6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC50 values of 4.5 and 2.8 mu M, respectively.
引用
收藏
页码：4486 / 4489
页数：4
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