SPRED proteins provide a NF-ty link to Ras suppression

被引：9

作者：

McClatchey, Andrea I. ^{[1
]}

Cichowski, Karen ^{[2
,3
,4
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Canc Res,Dept Pathol, Charlestown, MA 02129 USA

[2] Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Harvard Canc Ctr, Ludwig Ctr Dana Farber, Boston, MA 02115 USA

来源：

GENES & DEVELOPMENT | 2012年 / 26卷 / 14期

关键词：

Legius syndrome; NF1; signal transduction; Ras/MAPK; Sprouty; NEUROFIBROMATOSIS TYPE-1 PROTEIN; TUMOR-SUPPRESSOR; LEGIUS SYNDROME; SPROUTY; PHENOTYPE; GAP; ACTIVATION; MUTATIONS; MECHANISM; GENOTYPE;

D O I：

10.1101/gad.197434.112

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mutations in the SPRED1 (Sprouty-related protein with an EVH [Ena/Vasp homology] domain 1) and NF1 (neurofibromatosis 1) genes underlie clinically related human disorders. The NF1-encoded protein neurofibromin is a Ras GTPase-activating protein (GAP) and can directly limit Ras activity. Spred proteins also negatively regulate Ras signaling, but the mechanism by which they do so is not clear. In the July 1, 2012, issue of Genes & Development, Stowe and colleagues (pp. 1421-1426) present evidence that Spred1 recruits neurofibromin to the membrane, where it dampens growth factor-induced Ras activity, providing a satisfying explanation for the overlapping features of two human diseases.

引用

页码：1515 / 1519

页数：5

共 33 条

[1] RAS REGULATION - NF IS ENOUGH OF GAP
BOLLAG, G
MCCORMICK, F
[J]. NATURE, 1992, 356 (6371) : 663 - 664
[2] CHARACTERIZATION OF FULL-LENGTH NEUROFIBROMIN - TUBULIN INHIBITS RAS GAP ACTIVITY
BOLLAG, G
MCCORMICK, F
CLARK, R
[J]. EMBO JOURNAL, 1993, 12 (05) : 1923 - 1927
[3] Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype
Brems, Hilde
Chmara, Magdalena
Sahbatou, Mourad
Denayer, Ellen
Taniguchi, Koji
Kato, Reiko
Somers, Riet
Messiaen, Ludwine
De Schepper, Sofie
Fryns, Jean-Pierre
Cools, Jan
Marynen, Peter
Thomas, Gilles
Yoshimura, Akihiko
Legius, Eric
[J]. NATURE GENETICS, 2007, 39 (09) : 1120 - 1126
[4] Getting a first clue about SPRED functions
Bundschu, Karin
Walter, Ulrich
Schuh, Kai
[J]. BIOESSAYS, 2007, 29 (09) : 897 - 907
[5] Sprouty proteins, masterminds of receptor tyrosine kinase signaling
Cabrita, Miguel A.
Christofori, Gerhard
[J]. ANGIOGENESIS, 2008, 11 (01) : 53 - 62
[6] Sprouty, an intracellular inhibitor of Ras signaling
Casci, T
Vinós, J
Freeman, M
[J]. CELL, 1999, 96 (05) : 655 - 665
[7] Negative Feedback and Adaptive Resistance to the Targeted Therapy of Cancer
Chandarlapaty, Sarat
[J]. CANCER DISCOVERY, 2012, 2 (04) : 311 - 319
[8] Comprehensive genomic characterization defines human glioblastoma genes and core pathways
Chin, L.
Meyerson, M.
Aldape, K.
Bigner, D.
Mikkelsen, T.
VandenBerg, S.
Kahn, A.
Penny, R.
Ferguson, M. L.
Gerhard, D. S.
Getz, G.
Brennan, C.
Taylor, B. S.
Winckler, W.
Park, P.
Ladanyi, M.
Hoadley, K. A.
Verhaak, R. G. W.
Hayes, D. N.
Spellman, Paul T.
Absher, D.
Weir, B. A.
Ding, L.
Wheeler, D.
Lawrence, M. S.
Cibulskis, K.
Mardis, E.
Zhang, Jinghui
Wilson, R. K.
Donehower, L.
Wheeler, D. A.
Purdom, E.
Wallis, J.
Laird, P. W.
Herman, J. G.
Schuebel, K. E.
Weisenberger, D. J.
Baylin, S. B.
Schultz, N.
Yao, Jun
Wiedemeyer, R.
Weinstein, J.
Sander, C.
Gibbs, R. A.
Gray, J.
Kucherlapati, R.
Lander, E. S.
Myers, R. M.
Perou, C. M.
McLendon, Roger
[J]. NATURE, 2008, 455 (7216) : 1061 - 1068
[9] NF1 tumor suppressor gene function: Narrowing the GAP
Cichowski, K
Jacks, T
[J]. CELL, 2001, 104 (04) : 593 - 604
[10] Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor
Cichowski, K
Santiago, S
Jardim, M
Johnson, BW
Jacks, T
[J]. GENES & DEVELOPMENT, 2003, 17 (04) : 449 - 454

← 1 2 3 4 →