Regulation of Transforming Growth Factor-β1 Activation and Expression in the Tissue Remodeling Involved in Chronic Rhinosinusitis

被引：20
作者：
Kou, Wei [1 ]
Hu, Guo-Hua [1 ]
Yao, Hong-Bing [2 ]
Wang, Xiao-qiang [1 ]
Shen, Yang [1 ]
Kang, Hong-Yong [1 ]
Hong, Su-Ling [1 ]
机构：
[1] Chongqing Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Affiliated Hosp 1, Chongqing 400016, Peoples R China
[2] Chongqing Med Univ, Dept Otolaryngol, Childrens Hosp, Chongqing 400016, Peoples R China
来源：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY | 2012年 / 74卷 / 03期
关键词：
Chronic rhinosinusitis; Tissue remodeling; Transforming growth factor-beta 1; Dysregulation; NASAL POLYPOSIS; MATRIX METALLOPROTEINASES; BINDING-PROTEINS; INFLAMMATION; RECEPTOR; INTEGRIN; TRANSFORMING-GROWTH-FACTOR-BETA-1; HOMEOSTASIS; EOSINOPHIL; INHIBITOR;
D O I：
10.1159/000338799
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Transforming growth factor-beta 1 (TGF-beta 1) plays a key role in the tissue remodeling processes involved in chronic rhinosinusitis (CRS), with the biological functions of secreted TGF-beta 1 regulated by multiple proteins. Among these regulators, latency-associated peptide and latent TGF-beta 1-binding protein inhibit TGF-beta 1 function, whereas different proteases and integrins activate it. Progress in understanding the factors responsible for the bioactivity and expression of TGF-beta 1 has revealed that the dysregulation of TGF-beta 1 activation and expression is closely associated with the chronic respiratory inflammatory diseases involved in CRS. This review of the regulation of TGF-beta 1 activation and expression provides insight into the mechanism responsible for the different CRS subtypes, which will help further the investigation of novel therapy targets for the treatment of CRS. Copyright (c) 2012 S. Karger AG, Basel
引用
收藏
页码：172 / 178
页数：7
相关论文
共 41 条
  • [1] Inhibition of airway remodeling in IL-5-deficient mice
    Cho, JY
    Miller, M
    Baek, KJ
    Han, JW
    Nayar, J
    Lee, SY
    McElwain, K
    McElwain, S
    Friedman, S
    Broide, DH
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (04) : 551 - 560
  • [2] Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics
    Flood-Page, P
    Menzies-Gow, A
    Phipps, S
    Ying, S
    Wangoo, A
    Ludwig, MS
    Barnes, N
    Robinson, D
    Kay, AB
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (07) : 1029 - 1036
  • [3] Fokkens W, 2007, Rhinol, P1
  • [4] Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner
    Gomez-Duran, Aurea
    Ballestar, Esteban
    Carvajal-Gonzalez, Jose M.
    Marlowe, Jennifer L.
    Puga, Alvaro
    Esteller, Manel
    Fernandez-Salguero, Pedro M.
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2008, 380 (01) : 1 - 16
  • [5] Fitting a xenobiotic receptor into cell homeostasis: How the dioxin receptor interacts with TGFβ signaling
    Gomez-Duran, Aurea
    Carvajal-Gonzalez, Jose M.
    Mulero-Navarro, Sonia
    Santiago-Josefat, Belen
    Puga, Alvaro
    Fernandez-Salguero, Pedro M.
    [J]. BIOCHEMICAL PHARMACOLOGY, 2009, 77 (04) : 700 - 712
  • [6] Current concepts in therapy of chronic rhinosinusitis and nasal polyposis
    Gosepath, J
    Mann, WJ
    [J]. ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES, 2005, 67 (03): : 125 - 136
  • [7] Chronic rhinosinusitis: Epidemiology and medical management
    Hamilos, Daniel L.
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (04) : 693 - 709
  • [8] Hamilos DL, 1998, CLIN EXP ALLERGY, V28, P1145
  • [9] The pathogenesis of nasal polyposis by immunoglobulin E and interleukin-5 is completed by transforming growth factor-β1
    Hirschberg, A
    Jókúti, A
    Darvas, Z
    Almay, K
    Répássy, G
    Falus, A
    [J]. LARYNGOSCOPE, 2003, 113 (01) : 120 - 124
  • [10] Anti-latent TGF-β binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells
    Hori, Y
    Katoh, T
    Hirakata, M
    Joki, N
    Kaname, S
    Fukagawa, M
    Okuda, T
    Ohashi, H
    Fujita, T
    Miyazono, K
    Kurokawa, K
    [J]. KIDNEY INTERNATIONAL, 1998, 53 (06) : 1616 - 1625
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