TPS monitoring in metastatic breast cancer

被引：10
作者：
van Dalen, A [1 ]
机构：
[1] Tumor Marker Oncol, NL-2801 TG Gouda, Netherlands
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 1999年 / 14卷 / 01期
关键词：
breast cancer; TPS; cytokevatins; monitoring;
D O I：
10.1177/172460089901400109
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The management of metastatic breast cancer patients reflects the heterogeneous nature of the disease. While patients may benefit from hormonal treatment in most cases more toxic chemotherapy is applied in the advanced stages. The pretreatment levels of TPS in patients with metastatic breast cancer are correlated with prognosis. Decreasing TPS levels (>50%) during treatment are indicative of response. The fastest decrease in TPS levels is obtained in patients with a favorable prognosis. Increasing TPS levels (>25%) predict disease progression with a considerable lead time (median 8 months). The clinical impact of these observations is discussed in this paper.
引用
收藏
页码：45 / 48
页数：4
相关论文
共 22 条
[1]  
Barak V, 1997, J TUMOR MARKER ONCOL, V12, P17
[2]  
Blijlevens NMA, 1995, ANTICANCER RES, V15, P2711
[3]  
BONFRER JMG, 1990, TUMOR BIOL, V11, P278
[4]  
GERAGHTY JG, 1992, CANCER, V70, P2831, DOI 10.1002/1097-0142(19921215)70:12<2831::AID-CNCR2820701218>3.0.CO
[5]  
2-8
[6]  
Giai M, 1996, ANTICANCER RES, V16, P875
[7]  
GION M, 1992, BREAST, V1, P173
[8]   ASSESSMENT OF RESPONSE TO THERAPY IN ADVANCED BREAST-CANCER - PROJECT OF PROGRAM ON CLINICAL ONCOLOGY OF "INTERNATIONAL-UNION-AGAINST-CANCER, GENEVA, SWITZERLAND [J].
HAYWARD, JL ;
CARBONE, PP ;
HEUSON, JC ;
KUMAOKA, S ;
SEGALOFF, A ;
RUBENS, RD .
EUROPEAN JOURNAL OF CANCER, 1977, 13 (01) :89-94
[9]  
LAMERZ R, 1980, ONCODEV BIOL MED, V1, P123
[10]   USE OF SERIAL CARCINOEMBRYONIC ANTIGEN AND CA-15.3 ASSAYS IN DETECTING RELAPSES IN BREAST-CANCER PATIENTS [J].
MOLINA, R ;
ZANON, G ;
FILELLA, X ;
MORENO, F ;
JO, J ;
DANIELS, M ;
LATRE, ML ;
GIMENEZ, N ;
PAHISA, J ;
VELASCO, M ;
BALLESTA, AM .
BREAST CANCER RESEARCH AND TREATMENT, 1995, 36 (01) :41-48
123