Pre-miRNA expressing plasmid delivery for anticancer therapy

被引：3

作者：

Benisvy-Aharonovich, Elena ^{[1
]}

Shimanovich, Ulyana ^{[1
]}

Kronfeld, Noam ^{[2
]}

Giladi, Nis ^{[2
]}

Bier, Ariel ^{[2
]}

Kazimirsky, Gila ^{[2
]}

Gedanken, Aharon ^{[1
]}

Brodie, Chaya ^{[2
]}

机构：

[1] Bar Ilan Univ, Dept Chem, Inst Nanotechnol & Adv Mat, IL-52900 Ramat Gan, Israel

[2] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel

来源：

MEDCHEMCOMM | 2014年 / 5卷 / 04期

关键词：

GOLD NANOPARTICLES; GENE-REGULATION; MICRORNAS; GROWTH; DESIGN; GLIOMA;

D O I：

10.1039/c3md00314k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation of Au NP complexes of the premiRNA-145/GFP expressing plasmid is reported; the latter is successfully delivered to glioma cells and the transcripted miRNA-145 efficiently decreases the expression of its target gene, connective tissue growth factor (CTGF).

引用

页码：459 / 462

页数：4

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