Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent

被引：163

作者：

Wisnovsky, Simon P. ^{[1
]}

Wilson, Justin J. ^{[2
]}

Radford, Robert J. ^{[2
]}

Pereira, Mark P. ^{[1
]}

Chan, Maria R. ^{[2
]}

Laposa, Rebecca R. ^{[3
]}

Lippard, Stephen J. ^{[2
]}

Kelley, Shana O. ^{[1
,4
]}

机构：

[1] Univ Toronto, Fac Med, Dept Biochem, Toronto, ON M5S 1A8, Canada

[2] MIT, Dept Chem, Cambridge, MA 02139 USA

[3] Univ Toronto, Fac Med, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada

[4] Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, Toronto, ON M5S 3M2, Canada

来源：

CHEMISTRY & BIOLOGY | 2013年 / 20卷 / 11期

关键词：

OVARIAN-CARCINOMA CELLS; PENETRATING PEPTIDES; CANCER-CELLS; PREFERENTIAL BINDING; CISPLATIN; COMPLEXES; RESISTANCE;

D O I：

10.1016/j.chembiol.2013.08.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without damaging nuclear DNA, indicating that mtDNA damage is sufficient to mediate the activity of a platinum-based chemotherapeutic. This study demonstrates the specific delivery of a platinum drug to mitochondria and investigates the effects of directing this agent outside the nucleus.

引用

页码：1323 / 1328

页数：6

共 29 条

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