Adenovirus sensing by the immune system

被引：44

作者：

Atasheva, Svetlana ^{[1
]}

Shayakhmetov, Dmitry M. ^{[1
,2
]}

机构：

[1] Emory Univ, Div Rheumatol, Dept Pediat, 1760 Haygood Dr, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Med, Lowance Ctr Human Immunol, Emory Childrens Ctr Transplantat & Immune Mediate, 1760 Haygood Dr, Atlanta, GA 30322 USA

来源：

CURRENT OPINION IN VIROLOGY | 2016年 / 21卷

基金：

美国国家卫生研究院;

关键词：

INNATE IMMUNITY; KUPFFER CELLS; RECEPTOR; TRIGGERS; VECTORS; DNA; TRANSDUCTION; ANTIBODIES; INFECTION; RESPONSES;

D O I：

10.1016/j.coviro.2016.08.017

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The host immune system developed multiple ways for recognition of viral pathogens. Upon disseminated adenovirus infection, the immune system senses adenovirus invasion from the moment it enters the bloodstream. The soluble blood factors, FX, antibodies, and complement, can bind and activate plethora of host-protective immune responses. Adenovirus binding to the cellular 133 integrin and endosomal membrane rupture trigger activation of IL-1 alpha/IL-1R1 proinflammatory cascade leading to attraction of cytotoxic immune cells to the site of infection. Upon cell entry, adenovirus exposes its DNA genome in the cytoplasm and triggers DNA sensors signaling. Even when inside the nucleus, the specialized cellular machinery that recognizes the double-strand DNA breaks become activated and triggers viral DNA replication arrest. Thus, the host employs very diverse mechanisms to prevent viral dissemination.

引用

页码：109 / 113

页数：5

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