Gold-Catalyzed Redox Synthesis of ImidazoACHTUNGTRENUNG[ 1,2-a] pyridines using Pyridine N- Oxide and Alkynes

被引：65

作者：

Talbot, Eric P. A. ^{[1
,2
]}

Richardson, Melodie ^{[1
]}

McKenna, Jeffrey M. ^{[1
]}

Toste, F. Dean ^{[2
]}

机构：

[1] Novartis Inst Biomed Res, Horsham RH12 5AB, W Sussex, England

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 04期

关键词：

alkynes; atom economy; gold; imidazo[1; 2-a]pyridines; pyridine N-oxides; redox reaction; ONE-POT SYNTHESIS; ORGANIC-SYNTHESIS; AZOMETHINE YLIDES; ANTIVIRAL AGENTS; 2-AMINOPYRIDINES; 3-COMPONENT; CASCADE; CYCLOISOMERIZATION; REARRANGEMENTS; CYCLOADDITION;

D O I：

10.1002/adsc.201300996

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A mild, catalytic, atom economical synthesis of imidazo[1,2-a]pyridines has been developed: catalytic dichloro(2-pyridinecarboxylato)gold [PicAuCl(2)] in the presence of an acid produces a range of imidazo[1,2-a]pyridines in good yields starting from alkynes and 2-aminopyridine N-oxides. This strategy is mild and foreseen to be of particular use for the installation of stereogenic centers adjacent to the imidazo[1,2-a]pyridine ring without loss of enantiomeric excess.

引用

页码：687 / 691

页数：5

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