Clinical Efficacy and Safety of Chinese Herbal Medicine in the Treatment of Uremic Pruritus: A Meta-Analysis of Randomized Controlled Trials

被引：1
作者：
Lu, Ping-Hsun [1 ,2 ]
Lai, Chien-Cheng [3 ]
Lin, I-Hsin [2 ]
Tsai, Fu-Ming [4 ]
Lu, Po-Hsuan [5 ,6 ]
机构：
[1] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Chinese Med, New Taipei 23142, Taiwan
[2] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, Hualien 97048, Taiwan
[3] MacKay Mem Hosp, Dept Med Educ, Taipei 10449, Taiwan
[4] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Res, New Taipei 23142, Taiwan
[5] MacKay Mem Hosp, Dept Dermatol, Taipei 10449, Taiwan
[6] MacKay Med Coll, Dept Med, New Taipei 23142, Taiwan
来源：
PHARMACEUTICALS | 2022年 / 15卷 / 10期
关键词：
uremic pruritus; chronic kidney disease; chronic renal failure; Chinese herbal medicine; systematic review; meta-analysis; CHRONIC KIDNEY-DISEASE; QUALITY-OF-LIFE; HEMODIALYSIS-PATIENTS; TOPICAL APPLICATION; INFLAMMATION; PATHOGENESIS; PROTEIN;
D O I：
10.3390/ph15101239
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Uremic pruritus is a disturbing and refractory symptom in patients with advanced chronic kidney disease. Chinese herbal medicine has been reported to alleviate uremic pruritus. To investigate the effects of Chinese herbal medicine, we conducted a systematic review and meta-analysis on patients with uremic pruritus. We searched databases (prior to 3 May 2022) for randomized controlled trials on the effects of Chinese herbal medicine in treating uremic pruritus. Our meta-analysis included 3311 patients from 50 randomized controlled trials. In patients with uremic pruritus, adjunctive Chinese herbal medicine significantly improved overall effectiveness (risk ratio 1.29, 95% CI 1.23 to 1.35), quality of life, renal function, reduced pruritus score, and inflammatory biomarkers compared to control groups with hemodialysis alone or with anti-pruritic treatments. Chinese herbal medicine treatment showed a time-dependent tendency in improving the visual analog scale of dialysis patients. Compared to control groups, no significantly higher risk of adverse events in patients taking Chinese herbal medicine (risk ratio 0.60, 95% CI 0.22 to 1.63). Chinese herbal medicine appears to be effective and safe in complementing the treatment of patients with uremic pruritus.
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页数：25
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