GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer

被引：22

作者：

Chen, Maxine M. ^{[1
]}

O'Mara, Tracy A. ^{[2
]}

Thompson, Deborah J. ^{[3
]}

Painter, Jodie N. ^{[2
]}

Attia, John ^{[4
,5
]}

Black, Amanda ^{[6
]}

Brinton, Louise ^{[6
]}

Chanock, Stephen ^{[6
]}

Chen, Chu ^{[7
]}

Cheng, Timothy H. T. ^{[8
]}

Cook, Linda S. ^{[9
,10
]}

Crous-Bou, Marta ^{[1
,11
,12
]}

Doherty, Jennifer ^{[13
]}

Friedenreich, Christine M. ^{[14
]}

Garcia-Closas, Montserrat ^{[6
,15
]}

Gaudet, Mia M. ^{[16
]}

Gorman, Maggie ^{[8
]}

Haiman, Christopher ^{[17
]}

Hankinson, Susan E. ^{[11
,12
,18
]}

Hartge, Patricia ^{[6
]}

Henderson, Brian E. ^{[17
]}

Hodgson, Shirley ^{[19
]}

Holliday, Elizabeth G. ^{[4
]}

Horn-Ross, Pamela L. ^{[20
]}

Hunter, David J. ^{[1
]}

Le Marchand, Loic ^{[21
]}

Liang, Xiaolin ^{[22
]}

Lissowska, Jolanta ^{[23
,24
]}

Long, Jirong ^{[25
]}

Lu, Lingeng ^{[26
]}

Magliocco, Anthony M. ^{[27
]}

Martin, Lynn ^{[8
]}

McEvoy, Mark ^{[5
]}

Olson, Sara H. ^{[22
]}

Orlow, Irene ^{[22
]}

Pooler, Loreall ^{[17
]}

Prescott, Jennifer ^{[11
,12
]}

Rastogi, Radhai ^{[22
]}

Rebbeck, Timothy R. ^{[28
]}

Risch, Harvey ^{[26
]}

Sacerdote, Carlotta ^{[29
,30
]}

Schumacher, Frederick ^{[17
]}

Setiawan, Veronica Wendy ^{[17
]}

Scott, Rodney J. ^{[4
,31
,32
]}

Sheng, Xin ^{[17
]}

Shu, Xiao-Ou ^{[25
]}

Turman, Constance ^{[1
]}

Van Den Berg, David ^{[17
]}

Wang, Zhaoming ^{[6
]}

Weiss, Noel S. ^{[33
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA

[2] QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Herston, Qld 4006, Australia

[3] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England

[4] John Hunter Hosp, Hunter Med Res Inst, Newcastle, NSW 2305, Australia

[5] Univ Newcastle, Sch Med & Publ Hlth, Ctr Clin Epidemiol & Biostat, Newcastle, NSW 2308, Australia

[6] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[7] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[8] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[9] Univ New Mexico, Albuquerque, NM 87131 USA

[10] Alberta Hlth Serv, Dept Populat Hlth Res, Div Canc Care, Calgary, AB, Canada

[11] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[12] Harvard Med Sch, Boston, MA 02115 USA

[13] Dartmouth Coll, Sch Med, Lebanon, NH 03755 USA

[14] Alberta Hlth Serv, Canc Control Alberta, Dept Canc Epidemiol & Prevent Res, Calgary, AB, Canada

[15] Inst Canc Res, Div Genet & Epidemiol, London, England

[16] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[17] Univ Southern Calif, Los Angeles, CA 90033 USA

[18] Univ Massachusetts, Dept Biostat & Epidemiol, Amherst, MA 01003 USA

[19] St Georges Univ London, Dept Clin Genet, London SW17 0RE, England

[20] Canc Prevent Inst Calif, Fremont, CA 94538 USA

[21] Univ Hawaii, Ctr Canc, Honolulu, HI 96813 USA

[22] Mem Sloan Kettering Canc Ctr, New York, NY 10065 USA

[23] M Sklodowska Curie Canc Ctr, Dept Canc Epidemiol & Prevent, Warsaw, Poland

[24] Inst Oncol, Warsaw, Poland

[25] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 27232 USA

[26] Yale Univ, Sch Publ Hlth, New Haven, CT 06510 USA

[27] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

[28] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

[29] Ctr Canc Prevent CPO Piemonte, Turin, Italy

[30] Human Genet Fdn HuGeF, Turin, Italy

[31] John Hunter Hosp, Hunter Area Pathol Serv, Newcastle, NSW 2305, Australia

[32] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW 2308, Australia

[33] Univ Washington, Seattle, WA 19024 USA

[34] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[35] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge CB1 8RN, England

来源：

HUMAN MOLECULAR GENETICS | 2016年 / 25卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金; 澳大利亚国家健康与医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; EPITHELIAL-MESENCHYMAL TRANSITION; PROSTATE-CANCER; POOR-PROGNOSIS; COLORECTAL-CANCER; COMMON VARIANTS; FAMILY-HISTORY; LUNG-CANCER; RISK LOCI; SOX4;

D O I：

10.1093/hmg/ddw092

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P<5 x 10(-8)) at 6p22.3 (rs1740828; P = 2.29 x 10(-8), OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

引用

页码：2612 / 2620

页数：9

共 50 条

[21] Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer An Updated Meta-Analysis Based on GWAS Results
Yao, Kunhou
Hua, Long
Wei, Lunshou
Meng, Jiming
Hu, Junhong
MEDICINE, 2015, 94 (46) : e1884
[22] Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal
Xiang, Ruidong
van den Berg, Irene
MacLeod, Iona M.
Daetwyler, Hans D.
Goddard, Michael E.
COMMUNICATIONS BIOLOGY, 2020, 3 (01)
[23] Folate intake and the risk of endometrial cancer: A meta-analysis
Du, Li
Wang, Yulong
Zhang, Hang
Zhang, Hong
Gao, Ying
ONCOTARGET, 2016, 7 (51) : 85176 - 85184
[24] GWAS-linked GAK locus in Parkinson's disease in Han Chinese and meta-analysis
Li, Nan-Nan
Chang, Xue-Li
Mao, Xue-Ye
Zhang, Jin-Hong
Zhao, Dong-Mei
Tan, Eng-King
Peng, Rong
HUMAN GENETICS, 2012, 131 (07) : 1089 - 1093
[25] Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
Anney, Richard J. L.
Ripke, Stephan
Anttila, Verneri
Grove, Jakob
Holmans, Peter
Huang, Hailiang
Klei, Lambertus
Lee, Phil H.
Medland, Sarah E.
Neale, Benjamin
Robinson, Elise
Weiss, Lauren A.
Zwaigenbaum, Lonnie
Yu, Timothy W.
Wittemeyer, Kerstin
Willsey, A. Jeremy
Wijsman, Ellen M.
Werge, Thomas
Wassink, Thomas H.
Waltes, Regina
Walsh, Christopher A.
Wallace, Simon
Vorstman, Jacob A. S.
Vieland, Veronica J.
Vicente, Astrid M.
vanEngeland, Herman
Tsang, Kathryn
Thompson, Ann P.
Szatmari, Peter
Svantesson, Oscar
Steinberg, Stacy
Stefansson, Kari
Stefansson, Hreinn
State, Matthew W.
Soorya, Latha
Silagadze, Teimuraz
Scherer, Stephen W.
Schellenberg, Gerard D.
Sandin, Sven
Sanders, Stephan J.
Saemundsen, Evald
Rouleau, Guy A.
Roge, Bernadette
Roeder, Kathryn
Roberts, Wendy
Reichert, Jennifer
Reichenberg, Abraham
Rehnstrom, Karola
Regan, Regina
Poustka, Fritz
MOLECULAR AUTISM, 2017, 8
[26] Association of CYP1B1 gene polymorphisms with susceptibility to endometrial cancer: a meta-analysis
Wang, Fang
Zou, Yan-Feng
Sun, Guo-Ping
Su, Hong
Huang, Fen
EUROPEAN JOURNAL OF CANCER PREVENTION, 2011, 20 (02) : 112 - 120
[27] Meta analysis identifies a novel susceptibility locus associated with heel bone strength in the Korean population
Hwang, Joo-Yeon
Kim, Young Jin
Choi, Bo Youl
Kim, Bong-Jo
Han, Bok-Ghee
BONE, 2016, 84 : 47 - 51
[28] Association between apolipoprotein E genotype and cancer susceptibility: a meta-analysis
Anand, R.
Prakash, S. S.
Veeramanikandan, R.
Kirubakaran, Richard
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2014, 140 (07) : 1075 - 1085
[29] Association of CASP8 polymorphisms and cancer susceptibility: A meta-analysis
Hashemi, Mohammad
Aftabi, Sajjad
Moazeni-Roodi, Abdolkarim
Sarani, Hosna
Wiechec, Emilia
Ghavami, Saeid
EUROPEAN JOURNAL OF PHARMACOLOGY, 2020, 881
[30] XPA A23G polymorphism and susceptibility to cancer: a meta-analysis
Liu, Jun
Zhang, Zhen
Cao, Xiao-Lin
Lei, Da-Peng
Wang, Zhong-Qiu
Jin, Tong
Pan, Xin-Liang
MOLECULAR BIOLOGY REPORTS, 2012, 39 (06) : 6791 - 6799

← 1 2 3 4 5 →