Is It HIV TTP or HIV-Associated Thrombotic Microangiopathy?

被引：32

作者：

Brecher, Mark E. ^{[1
]}

Hay, Shauna N. ^{[1
]}

Park, Yara A. ^{[1
]}

机构：

[1] UNC Hosp, Dept Pathol & Lab Med, Chapel Hill, NC 27514 USA

来源：

JOURNAL OF CLINICAL APHERESIS | 2008年 / 23卷 / 06期

关键词：

microangiopathy; HIV; TTP; ADAMTS13;

D O I：

10.1002/jca.20176

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombocytopenia is a common complication of Human Immunodeficiency Virus (HIV) infection. With,advanced HIV disease, the presence of both thromcytopenia and schistocytosis are frequently observed. In such cases, the diagnosis of HIV associated TTP is often considered. This article reviews emerging concepts of HIV associated mcroangiopathies. It concludes that the pathophysiology. in many cases seems to be distinct from idiopathic TTP (particularly with advanced HIV disease-< 100 CD4/microliter). A sine que non for successful therapy of HIV-TMA appears to be the treatment of the underlying HIV infection. J. Clin. Apheresis 23:186-190, 2008. (c) 2008 Wiley-Liss. Inc.

引用

页码：186 / 190

页数：5

共 51 条

[1]

BACHMEYER C, 1995, AIDS, V9, P532, DOI 10.1097/00002030-199509050-00022

[2] KINETIC-STUDIES OF THE MECHANISM OF THROMBOCYTOPENIA IN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].

BALLEM, PJ ;

BELZBERG, A ;

DEVINE, DV ;

LYSTER, D ;

SPRUSTON, B ;

CHAMBERS, H ;

DOUBROFF, P ;

MIKULASH, K .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (25) :1779-1784

[3]

Bandarenko N, 1998, J CLIN APHERESIS, V13, P133, DOI 10.1002/(SICI)1098-1101(1998)13:3<133::AID-JCA7>3.0.CO

[4]

2-Z

[5] HIV-associated thrombotic microangiopathy in the era of highly active antiretroviral therapy: An observational study [J].

Becker, S ;

Fusco, G ;

Fusco, J ;

Balu, R ;

Gangjee, S ;

Brennan, C ;

Feinberg, J .

CLINICAL INFECTIOUS DISEASES, 2004, 39 :S267-S275

[6] MICROANGIOPATHIC HAEMOLYTIC ANAEMIA - POSSIBLE ROLE OF VASCULAR LESIONS IN PATHOGENESIS [J].

BRAIN, MC ;

DACIE, JV ;

HOURIHANE, DOB .

BRITISH JOURNAL OF HAEMATOLOGY, 1962, 8 (04) :358-&

[7] Is It HIV TTP or HIV-Associated Thrombotic Microangiopathy? [J].

Brecher, Mark E. ;

Hay, Shauna N. ;

Park, Yara A. .

JOURNAL OF CLINICAL APHERESIS, 2008, 23 (06) :186-190

[8] How I approach a thrombotic thrombocytopenia purpura patient [J].

Brecher, ME .

TRANSFUSION, 2006, 46 (05) :687-689

[9]

CENACCHI G, 1992, J SUBMICR CYTOL PATH, V24, P155

[10] Productive human immunodeficiency virus-1 infection of purified megakaryocytic progenitors/precursors and maturing megakaryocytes [J].

Chelucci, C ;

Federico, M ;

Guerriero, R ;

Mattia, G ;

Casella, I ;

Pelosi, E ;

Testa, U ;

Mariani, G ;

Hassan, HJ ;

Peschle, C .

BLOOD, 1998, 91 (04) :1225-1234

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