Tryptophan restriction partially recapitulates the age-dependent effects of total amino acid restriction on energy balance in diet-induced obese rats

被引:12
作者
Zapata, Rizaldy C. [1 ]
Singh, Arashdeep [1 ]
Pezeshki, Adel [2 ]
Chelikani, Prasanth K. [1 ,3 ]
机构
[1] Univ Calgary, Fac Vet Med, Dept Prod Anim Hlth, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada
[2] Oklahoma State Univ, Dept Anim & Food Sci, 310 North Monroe St, Stillwater, OK 74078 USA
[3] Univ Calgary, Snyder Inst Chron Dis, Gastrointestinal Res Grp, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada
基金
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词
Protein restriction; Energy expenditure; Amino acid sensing; Tryptophan; Histidine; LOW-PROTEIN DIET; SYMPATHETIC-NERVE ACTIVITY; BROWN ADIPOSE-TISSUE; METHIONINE RESTRICTION; WEIGHT-LOSS; DECREASED CONSUMPTION; INDIRECT CALORIMETRY; BETA-KLOTHO; FOOD-INTAKE; GROWTH;
D O I
10.1016/j.jnutbio.2018.12.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Moderate dietary protein restriction promotes hyperphagia and thermogenesis; however, little is known of whether these responses are due to restriction of the essential amino acids tryptophan and histidine. Here, we determined whether restriction of tryptophan and histidine alone recapitulate the effects of total amino acid restriction on energy balance, and whether the metabolic responses are age-dependent. We fed young (12 weeks old) and older (29 weeks old) dietinduced obese rats with one of four high-fat diets: control (CON, 100% amino acid requirement), total amino acid restriction (TAA, 67% amino acid restriction), tryptophan restriction (TRP, 67% tryptophan restriction) or histidine restriction (HIS, 67% histidine restriction) for 21 days. Energy balance, hormones, and key markers of hepatic nutrient sensing and brown adipose thermogenesis were measured. We found that TM increased food intake in both young and older rats, with TRP, but not HIS, transiently simulating the hyperphagia. TM promoted sympathetically mediated increase in energy expenditure in young rats partly through increased 132-adrenergic and FGF21 signaling in brown fat; TRP partially emulated these responses. TRP and HIS transiently increased fat mass in young rats, and TM promoted adiposity in older rats. TM, TRP and HIS increased postprandial FGF21 concentrations in older rats. TAA induced age-dependent differential changes in markers of hepatic amino acid sensing; TRP and HIS partially mimicked these responses. Collectively, restriction of tryptophan, but not histidine, partially recapitulated the age-dependent metabolic effects of total amino acid restriction, in concert with distinct changes in hepatic amino acid sensing and signaling mechanisms. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码:115 / 127
页数:13
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