A prospective randomized multicenter comparative study of BLM-240 (desflurane) versus sevoflurane in Japanese patients

被引：1

作者：

Takeda, Junzo ^{[1
]}

Namiki, Akiyoshi ^{[2
]}

Ozaki, Makoto ^{[3
]}

Fukuda, Kazuhiko ^{[4
]}

Morita, Kiyoshi ^{[5
]}

Kanmura, Yuichi ^{[6
]}

Yamakage, Michiaki ^{[2
]}

Komatsu, Takami ^{[7
]}

Inada, Eiichi ^{[8
]}

Kawate, Ryoichi ^{[9
]}

Kanazawa, Masahiro ^{[10
]}

Sakamoto, Atsuhiro ^{[11
]}

Uezono, Shoichi ^{[12
]}

Sato, Shigehito ^{[13
]}

Nishiwaki, Kimitoshi ^{[14
]}

Miyamoto, Yoshikazu ^{[15
]}

Nakatsuka, Hideki ^{[5
]}

Yasuda, Nobuhiko ^{[16
]}

机构：

[1] Keio Univ, Dept Anesthesiol, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

[2] Sapporo Med Univ, Sch Med, Dept Anesthesiol, Sapporo, Hokkaido, Japan

[3] Tokyo Womens Med Univ, Dept Anesthesiol, Tokyo, Japan

[4] Kyoto Univ Hosp, Dept Anesthesiol, Kyoto 606, Japan

[5] Okayama Univ Hosp, Dept Anesthesiol & Resuscitol, Okayama, Japan

[6] Kagoshima Univ, Fac Med, Dept Anesthesiol & Crit Care Med, Kagoshima 890, Japan

[7] Univ Tokyo, Dept Anesthesiol, Tokyo, Japan

[8] Juntendo Univ, Sch Med, Dept Anesthesiol, Tokyo 113, Japan

[9] NTT Med Ctr Tokyo, Dept Anesthesia, Tokyo, Japan

[10] Tokai Univ, Dept Anesthesiol, Hiratsuka, Kanagawa 25912, Japan

[11] Nippon Med Sch, Dept Anesthesiol, Tokyo 113, Japan

[12] Jikei Univ, Dept Anesthesiol, Sch Med, Tokyo 105, Japan

[13] Hamamatsu Univ Sch Med, Dept Anesthesiol & Resuscitol, Shizuoka, Japan

[14] Nagoya Univ Hosp, Dept Anesthesiol, Nagoya, Aichi, Japan

[15] Osaka Univ Hosp, Dept Anesthesiol, Osaka 553, Japan

[16] Jikei Univ, Presidents Off, Tokyo, Japan

[17] Baxter Ltd, Tokyo, Japan

来源：

JOURNAL OF ANESTHESIA | 2013年 / 27卷 / 03期

关键词：

Desflurane; Sevoflurane; Inhalation; Anesthetic; ANESTHESIA; RECOVERY; ISOFLURANE; SURGERY;

D O I：

10.1007/s00540-012-1536-x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The present study was conducted to evaluate the efficacy and safety of BLM-240 (desflurane) in comparison to sevoflurane in Japanese patients. A total of 216 patients were enrolled in this randomized comparative study at 15 medical institutions. The patients received either BLM-240 with 50-70 % N2O in O-2 (n = 111), BLM-240 with 30 % O-2 in air (n = 55), or sevoflurane with 50-70 % N2O in O-2 (n = 50). Efficacy was evaluated by an efficacy rate based on an efficacy evaluation criteria and recovery time to extubation from the discontinuation of the anesthetics. Safety was evaluated by incidence of adverse drug reactions (ADR) and other clinical indicators. The efficacy rate of BLM-240 was 98.8 % (164/166 patients), indicating that BLM-240 is effective as an anesthetic. Time from discontinuation of anesthetic delivery to extubation was 9.7 +/- A 0.6 min in the BLM-240/N2O group and 14.3 +/- A 0.9 min in the sevoflurane/N2O group, meeting the pre-defined non-inferiority criteria of BLM-240 to sevoflurane. There was no statistically significant difference in the incidence of total ADR between the BLM-240 group (62.0 %) and sevoflurane group (48.0 %). The results indicate that BLM-240 is an effective and safe inhalation anesthetic in Japanese patients.

引用

页码：468 / 471

页数：4

共 9 条

[1] Baxter company internal report, 2009, FIN REP SAF PHARM BL
[2] Early Postoperative Cognitive Recovery and Gas Exchange Patterns After Balanced Anesthesia With Sevoflurane or Desflurane in Overweight and Obese Patients Undergoing Craniotomy A Prospective Randomized Trial
Bilotta, Federico
Doronzio, Andrea
Cuzzone, Vincenzo
Caramia, Remo
Rosa, Giovanni
[J]. JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2009, 21 (03) : 207 - 213
[3] Minimum alveolar concentration of desflurane with fentanyl for laryngeal mask airway removal in anesthetized children
Makkar, Jeetinder K.
Ghai, Babita
Bhardwaj, Neerja
Wig, Jyotsna
[J]. PEDIATRIC ANESTHESIA, 2012, 22 (04) : 335 - 340
[4] Effect of increased body mass index and anaesthetic duration on recovery of protective airway reflexes after sevoflurane vs desflurane†
McKay, R. E.
Malhotra, A.
Cakmakkaya, O. S.
Hall, K. T.
McKay, W. R.
Apfel, C. C.
[J]. BRITISH JOURNAL OF ANAESTHESIA, 2010, 104 (02) : 175 - 182
[5] Desflurane preconditioning in coronary artery bypass graft surgery: a double-blinded, randomised and placebo-controlled study
Meco, Massimo
Cirri, Silvia
Gallazzi, Chiara
Magnani, Giulia
Cosseta, Daniele
[J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2007, 32 (02) : 319 - 325
[6] Effects of sevoflurane and isoflurane anesthesia on arterial ketone body ratio and liver function
Nishiyama, T
Yokoyama, T
Hanaoka, K
[J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1999, 43 (03) : 347 - 351
[7] Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled trial
Roertgen, D.
Kloos, J.
Fries, M.
Grottke, O.
Rex, S.
Rossaint, R.
Coburn, M.
[J]. BRITISH JOURNAL OF ANAESTHESIA, 2010, 104 (02) : 167 - 174
[8] Desflurane vs. sevoflurane as the main inhaled anaesthetic for spontaneous breathing via a laryngeal mask for varicose vein day surgery: a prospective randomized study
Saros, GB
Doolke, A
Anderson, RE
Jakobsson, JG
[J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2006, 50 (05) : 549 - 552
[9] YASUDA N, 1989, ANESTH ANALG, V69, P370

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