Vaccine Designs Utilizing Invariant NKT-Licensed Antigen-Presenting Cells Provide NKT or T cell Help for B Cell Responses

被引:15
作者
Fujii, Shin-ichiro [1 ]
Yamasaki, Satoru [1 ]
Sato, Yusuke [1 ]
Shimizu, Kanako [1 ]
机构
[1] RIKEN Ctr Integrat Med Sci IMS, Lab Immunotherapy, Yokohama, Kanagawa, Japan
来源
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
关键词
NKT; Tfh; NKTfh; dendritic cell; vaccines; ALPHA-GALACTOSYLCERAMIDE; DENDRITIC CELLS; IMMUNE-RESPONSES; IN-VIVO; AFFINITY MATURATION; ANTIBODY-RESPONSES; ADAPTIVE IMMUNITY; DEFICIENT MICE; COGNATE HELP; INNATE;
D O I
10.3389/fimmu.2018.01267
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vaccines against a variety of infectious diseases have been developed and tested. Although there have been some notable successes, most are less than optimal or have failed outright. There has been discussion about whether either B cells or dendritic cells (DCs) could be useful for the development of antimicrobial vaccines with the production of high titers of antibodies. Invariant (i) NKT cells have direct antimicrobial effects as well as adjuvant activity, and iNKT-stimulated antigen-presenting cells (APCs) can determine the form of the ensuing humoral and cellular immune responses. In fact, upon activation by ligand, iNKT cells can stimulate both B cells and DCs as via either cognate or non-cognate help. iNKT-licensed DCs generate antigen-specific follicular helper CD4(+) T cells, which in turn stimulate B cells, thus leading to long-term antigen-specific antibody production. Follicular helper iNKT cell-licensed B cells generally produce rapid, but short-term antibody. However, under some conditions in the presence of Th cells, the antibody production can be prolonged. With regards to humoral immunity, the quality and quantity of Ab produced depends on the APC type and the form of the vaccine. In terms of cellular immunity and, in particular, the induction of cytotoxic CD8(+) T cells, iNKT-licensed DCs show prominent activity. In this review, we discuss differences in iNKT-stimulated APC types and the quality of the ensuing immune response, and also discuss their application in vaccine models to develop successful preventive immunotherapy against infectious diseases.
引用
收藏
页数:8
相关论文
共 62 条
[1]   The role of MHC class Ib-restricted T cells during infection [J].
Anderson, Courtney K. ;
Brossay, Laurent .
IMMUNOGENETICS, 2016, 68 (08) :677-691
[2]   Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides [J].
Bai, Li ;
Deng, Shenglou ;
Reboulet, Rachel ;
Mathew, Rebecca ;
Teyton, Luc ;
Savage, Paul B. ;
Bendelac, Albert .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (40) :16097-16102
[3]  
BANKS TA, 1995, J IMMUNOL, V155, P1685
[4]   B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo [J].
Barral, Patricia ;
Eckl-Dorna, Julia ;
Harwood, Naomi E. ;
De Santo, Carmela ;
Salio, Mariolina ;
Illarionov, Petr ;
Besra, Gurdyal S. ;
Cerundolo, Vincenzo ;
Batista, Facundo D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (24) :8345-8350
[5]   The location of splenic NKT cells favours their rapid activation by blood-borne antigen [J].
Barral, Patricia ;
Sanchez-Nino, Maria Dolores ;
van Rooijen, Nico ;
Cerundolo, Vincenzo ;
Batista, Facundo D. .
EMBO JOURNAL, 2012, 31 (10) :2378-2390
[6]   Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions [J].
Brennan, Patrick J. ;
Brigl, Manfred ;
Brenner, Michael B. .
NATURE REVIEWS IMMUNOLOGY, 2013, 13 (02) :101-117
[7]   Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity [J].
Calabro, Samuele ;
Liu, Dong ;
Gallman, Antonia ;
Nascimento, Manuela Sales L. ;
Yu, Zizi ;
Zhang, Ting-ting ;
Chen, Pei ;
Zhang, Biyan ;
Xu, Lan ;
Gowthaman, Uthaman ;
Krishnaswamy, Jayendra Kumar ;
Haberman, Ann M. ;
Williams, Adam ;
Eisenbarth, Stephanie C. .
CELL REPORTS, 2016, 16 (09) :2472-2485
[8]   Bridging channel dendritic cells induce immunity to transfused red blood cells [J].
Calabro, Samuele ;
Gallman, Antonia ;
Gowthaman, Uthaman ;
Liu, Dong ;
Chen, Pei ;
Liu, Jingchun ;
Krishnaswamy, Jayendra Kumar ;
Nascimento, Manuela Sales L. ;
Xu, Lan ;
Patel, Seema R. ;
Williams, Adam ;
Tormey, Christopher A. ;
Hod, Eldad A. ;
Spitalnik, Steven L. ;
Zimring, James C. ;
Hendrickson, Jeanne E. ;
Stowell, Sean R. ;
Eisenbarth, Stephanie C. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2016, 213 (06) :887-896
[9]   Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses [J].
Chang, Pheh-Ping ;
Barral, Patricia ;
Fitch, Jessica ;
Pratama, Alvin ;
Ma, Cindy S. ;
Kallies, Axel ;
Hogan, Jennifer J. ;
Cerundolo, Vincenzo ;
Tangye, Stuart G. ;
Bittman, Robert ;
Nutt, Stephen L. ;
Brink, Robert ;
Godfrey, Dale I. ;
Batista, Facundo D. ;
Vinuesa, Carola G. .
NATURE IMMUNOLOGY, 2012, 13 (01) :35-U56
[10]   Dynamic regulation of BcI6 in follicular helper CD4 T (Tfh) cells [J].
Choi, Youn Soo ;
Yang, Jessica A. ;
Crotty, Shane .
CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (03) :366-372