Polymorphism of IL-1RA and TNF-alpha genes in patients with Helicobacter pylori associated gastritis and duodenal ulcer

The goal of this work was to determine the frequency of major types of polymorphism in the genes of interleukin-1 receptor antagonist (IL-1RA) and TNF-alpha in patients with Helicobacter pylori-associated gastritis and duodenal ulcer and elucidate its correlation with clinical manifestation of the disease. A total of 126 patients were selected for the study with different gastroduodenal pathologies and H. pylori detected in biopsy material. The obtained data indicate a possible correlation between the risk of developing duodenal ulcer and the presence of the allele A in the TNF-alpha gene at the -308 position in the patients. Polymorphism analysis of the IL-1RA gene revealed a statistically significant difference in the availability of the 2/L genotype in the studied groups of patients. The conducted research demonstrates that a parallel typing of the H. pylori virulence genes and determination of the cytokine gene polymorphism in the biopsy material taken from the patient is required for characterization of the bacterium-host interaction.