IMGT®, the international ImMunoGeneTics information system®

被引：571

作者：

Lefranc, Marie-Paule ^{[1
]}

Giudicelli, Veronique ^{[1
]}

Ginestoux, Chantal ^{[1
]}

Jabado-Michaloud, Joumana ^{[1
]}

Folch, Geraldine ^{[1
]}

Bellahcene, Fatena ^{[1
]}

Wu, Yan ^{[1
]}

Gemrot, Elodie ^{[1
]}

Brochet, Xavier ^{[1
]}

Lane, Jerome ^{[1
]}

Regnier, Laetitia ^{[1
]}

Ehrenmann, Francois ^{[1
]}

Lefranc, Gerard ^{[1
]}

Duroux, Patrice ^{[1
]}

机构：

[1] Univ Montpellier, UPR CNRS 1142, Int ImMunoGeneT Informat Syst, Lab ImmunoGenet Mol,Inst Genet Humaine,IMGT, F-34396 Montpellier 5, France

来源：

NUCLEIC ACIDS RESEARCH | 2009年 / 37卷

关键词：

T-CELL-RECEPTOR; IUIS NOMENCLATURE SUBCOMMITTEE; V-J; IMMUNOGLOBULIN; DATABASE; SEQUENCE; IG; ANNOTATION; ONTOLOGY; GENE;

D O I：

10.1093/nar/gkn838

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IMGT (R), the international ImMunoGeneTics information system (R) (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGenetique Moleculaire LIGM (Universite Montpellier 2 and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. The building of a unique ontology, IMGT-ONTOLOGY, has made IMGT (R) the global reference in immunogenetics and immunoinformatics. IMGT (R) is a high-quality integrated knowledge resource specialized in the immunoglobulins or antibodies, T cell receptors, major histocompatibility complex, of human and other vertebrate species, proteins of the IgSF and MhcSF, and related proteins of the immune systems of any species. IMGT (R) provides a common access to standardized data from genome, proteome, genetics and 3D structures. IMGT (R) consists of five databases (IMGT/LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB, etc.), fifteen interactive online tools for sequence, genome and 3D structure analysis, and more than 10 000 HTML pages of synthesis and knowledge. IMGT (R) is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas and myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow-up of residual diseases) and therapeutical approaches (graft, immunotherapy, vaccinology). IMGT is freely available at http://www.imgt.org.

引用

页码：D1006 / D1012

页数：7

共 39 条

[1] IMGT/GeneInfo: T cell receptor gamma TRG and delta TRD genes in database give access to all TR potential V(D)J recombinations [J].

Baum, Thierry-Pascal ;

Hierle, Vivien ;

Pasqual, Nicolas ;

Bellahcene, Fatena ;

Chaume, Denys ;

Lefranc, Marie-Paule ;

Jouvin-Marche, Evelyne ;

Marche, Patrice Noel ;

Demongeot, Jacques .

BMC BIOINFORMATICS, 2006, 7 (1)

[2]

Benson DA, 2017, NUCLEIC ACIDS RES, V45, pD37, DOI [10.1093/nar/gkl986, 10.1093/nar/gkw1070, 10.1093/nar/gkg057, 10.1093/nar/gks1195, 10.1093/nar/gkp1024, 10.1093/nar/gkq1079, 10.1093/nar/gkr1202, 10.1093/nar/gkx1094, 10.1093/nar/gkn723]

[3] IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis [J].

Brochet, Xavier ;

Lefranc, Marie-Paule ;

Giudicelli, Veronique .

NUCLEIC ACIDS RESEARCH, 2008, 36 :W503-W508

[4] The HGNC Database in 2008: a resource for the human genome [J].

Bruford, Elspeth A. ;

Lush, Michael J. ;

Wright, Mathew W. ;

Sneddon, Tam P. ;

Povey, Sue ;

Birney, Ewan .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D445-D448

[5] The Mouse Genome Database (MGD): mouse biology and model systems [J].

Bult, Carol J. ;

Eppig, Janan T. ;

Kadin, James A. ;

Richardson, Joel E. ;

Blake, Judith A. .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D724-D728

[6] Priorities for nucleotide trace, sequence and annotation data capture at the Ensembl Trace Archive and the EMBL Nucleotide Sequence Database [J].

Cochrane, Guy ;

Akhtar, Ruth ;

Aldebert, Philippe ;

Althorpe, Nicola ;

Baldwin, Alastair ;

Bates, Kirsty ;

Bhattacharyya, Sumit ;

Bonfield, James ;

Bower, Lawrence ;

Browne, Paul ;

Castro, Matias ;

Cox, Tony ;

Demiralp, Fehmi ;

Eberhardt, Ruth ;

Faruque, Nadeem ;

Hoad, Gemma ;

Jang, Mikyung ;

Kulikova, Tamara ;

Labarga, Alberto ;

Leinonen, Rasko ;

Leonard, Steven ;

Lin, Quan ;

Lopez, Rodrigo ;

Lorenc, Dariusz ;

McWilliam, Hamish ;

Mukherjee, Gaurab ;

Nardone, Francesco ;

Plaister, Sheila ;

Robinson, Stephen ;

Sobhany, Siamak ;

Vaughan, Robert ;

Wu, Dan ;

Zhu, Weimin ;

Apweiler, Rolf ;

Hubbard, Tim ;

Birney, Ewan .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D5-D12

[7] IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm [J].

Duroux, Patrice ;

Kaas, Quentin ;

Brochet, Xavier ;

Lane, Jerome ;

Ginestoux, Chantal ;

Lefranc, Marie-Paule ;

Giudicelli, Veronique .

BIOCHIMIE, 2008, 90 (04) :570-583

[8] Sequence Ontology Annotation Guide [J].

Eilbeck, K ;

Lewes, SE .

COMPARATIVE AND FUNCTIONAL GENOMICS, 2004, 5 (08) :642-647

[9] IMGT/PhyloGene: an on-line tool for comparative analysis of immunoglobulin and T cell receptor genes [J].

Elemento, O ;

Lefranc, MP .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2003, 27 (09) :763-779

[10]

FOLCH G, 2004, NUCLEIC ACIDS RES, V32, P3

← 1 2 3 4 →