N-heterocyclic carbene complexes of silver and gold as novel tools against breast cancer progression

被引：55

作者：

Saturnino, Carmela ^{[1
]}

Barone, Ines ^{[2
]}

Iacopetta, Domenico ^{[2
]}

Mariconda, Annaluisa ^{[3
]}

Sinicropi, Maria Stefania ^{[1
]}

Rosano, Camillo ^{[4
]}

Campana, Antonella ^{[2
]}

Catalano, Stefania ^{[2
]}

Longo, Pasquale ^{[3
]}

Ando, Sebastiano ^{[2
]}

机构：

[1] Univ Salerno, Dept Pharm, I-84084 Salerno, Italy

[2] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy

[3] Univ Salerno, Dept Chem & Biol, I-84084 Salerno, Italy

[4] IRCCS AOU San Martino IST, Natl Inst Canc Res, UOS Prote, Largo R Benzi 10, Genoa, Italy

来源：

FUTURE MEDICINAL CHEMISTRY | 2016年 / 8卷 / 18期

关键词：

breast cancer; mitochondria; N-heterocyclic carbene complexes; p53; Sp1; transmetallation; METAL-COMPLEXES; SILVER(I)-CARBENE COMPLEXES; ANTIPROLIFERATIVE ACTIVITY; CYTOTOXIC ACTIVITY; CELLS; P53; LIGANDS; MITOCHONDRIA; DERIVATIVES; INHIBITION;

D O I：

10.4155/fmc-2016-0160

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aim: Metal carbenic complexes have received considerable attention in both the catalysis and biological fields for their potential applications in cancer and antimicrobial therapies. Results: A small series of new silver and gold N-heterocyclic carbene complexes has been designed and synthesized. Among the tested complexes, one compound was particularly active in inhibiting anchorage-dependent and -independent breast cancer proliferation, and inducing cell apoptosis via a mitochondria-related process. The antitumor activity was associated to the transcriptional activation of the tumor suppressor gene p53 in an Sp1-dependent manner, as evidenced by biological and docking studies. Conclusion: Our results highlight the importance and the versatility of N-heterocyclic carbene complexes of gold and silver as useful tools against breast cancer progression.

引用

页码：2213 / 2229

页数：17

共 65 条

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