The Flow brain stimulation headset for the treatment of depression: overview of its safety, efficacy and portable design

被引：12
作者：
Borrione, Lucas [1 ,2 ,3 ]
Suen, Paulo J. C. [2 ,3 ]
Razza, Lais B. [1 ,2 ,3 ]
Dos Santos, Leonardo Afonso [1 ,2 ,3 ]
Sudbrack-Oliveira, Pedro [1 ,2 ,3 ]
Brunoni, Andre R. [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Sao Paulo, Med Sch, Dept & Inst Psychiat, Serv Interdisciplinary Neuromodulat, Sao Paulo, Brazil
[2] Univ Sao Paulo, Med Sch, Dept & Inst Psychiat, Lab Neurosci, Sao Paulo, Brazil
[3] Univ Sao Paulo, Med Sch, Dept & Inst Psychiat, Natl Inst Biomarkers Psychiat, Sao Paulo, Brazil
[4] Univ Sao Paulo, Med Sch, Dept Internal Med, Sao Paulo, Brazil
[5] Univ Sao Paulo, Univ Hosp, Sao Paulo, Brazil
来源：
EXPERT REVIEW OF MEDICAL DEVICES | 2020年 / 17卷 / 09期
基金：
巴西圣保罗研究基金会;
关键词：
App; psychotherapy; major depressive disorder; neuromodulation; transcranial direct current stimulation; 2016 CLINICAL GUIDELINES; ELECTRICAL-CURRENT THERAPY; MOTOR CORTEX; TREATING DEPRESSION; ANXIETY TREATMENTS; CANADIAN NETWORK; DOUBLE-BLIND; DISORDER; TDCS; METAANALYSIS;
D O I：
10.1080/17434440.2020.1813565
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Introduction Major depressive disorder (MDD) is a prevalent and debilitating condition. First-line treatments include antidepressants and cognitive-behavioral psychotherapy (CBT). However, several patients present treatment-resistance and/or adverse effects. Transcranial direct current stimulation (tDCS), a noninvasive neuromodulation technique, is an effective alternative for MDD. Areas covered We hereby review a portable tDCS device designed to be combined with a cognitive-behavioral intervention. This home-use device was developed by Flow Neuroscience (TM) and was recently approved in the UK and European Union. We discuss present evidence on tDCS efficacy and safety, both as a monotherapy and as a combined treatment. Moreover, we show a computer modeling tDCS procedure based on Flow parameters and montage. Expert opinion Electric field simulations revealed that Flow's tDCS device targets prefrontal cortical areas involved in MDD pathophysiology. In addition, the safety and efficacy profile revealed from prior tDCS studies support its use in depression. Finally, combining tDCS with cognitive-behavioral interventions might further enhance overall efficacy, although this aspect should be investigated in upcoming randomized, placebo-controlled trials.
引用
收藏
页码：867 / 878
页数：12
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