Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data

被引：680

作者：

Rudin, Charles M. ^{[1
]}

Poirier, John T. ^{[1
]}

Byers, Lauren Averett ^{[2
]}

Dive, Caroline ^{[3
]}

Dowlati, Afshin ^{[4
]}

George, Julie ^{[5
]}

Heymach, John, V ^{[2
]}

Johnson, Jane E. ^{[6
]}

Lehman, Jonathan M. ^{[7
]}

MacPherson, David ^{[8
]}

Massion, Pierre P. ^{[7
]}

Minna, John D. ^{[6
]}

Oliver, Trudy G. ^{[9
]}

Quaranta, Vito ^{[7
]}

Sage, Julien ^{[10
]}

Thomas, Roman K. ^{[5
]}

Vakoc, Christopher R. ^{[11
]}

Gazdar, Adi F. ^{[6
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[2] Univ Texas Houston, MD Anderson Canc Ctr, 1515 Holcombe Blvd, Houston, TX 77030 USA

[3] Univ Manchester, Manchester, Lancs, England

[4] Case Western Reserve Univ, Cleveland, OH 44106 USA

[5] Univ Cologne, Cologne, Germany

[6] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA

[7] Vanderbilt Univ, Med Ctr, Nashville, TN USA

[8] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[9] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA

[10] Stanford Univ, Palo Alto, CA 94304 USA

[11] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

来源：

NATURE REVIEWS CANCER | 2019年 / 19卷 / 05期

基金：

美国国家卫生研究院;

关键词：

NEUROENDOCRINE DIFFERENTIATION; TRANSCRIPTION FACTOR; INSM1; IA-1; HETEROGENEITY; EXPRESSION; SCLC; ADENOCARCINOMAS; NETWORK; TUMORS; LINES;

D O I：

10.1038/s41568-019-0133-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a new model of SCLC subtypes defined by differential expression of four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). In this Perspectives article, we review and synthesize these recent lines of evidence and propose a working nomenclature for SCLC subtypes defined by relative expression of these four factors. Defining the unique therapeutic vulnerabilities of these subtypes of SCLC should help to focus and accelerate therapeutic research, leading to rationally targeted approaches that may ultimately improve clinical outcomes for patients with this disease.

引用

页码：289 / 297

页数：9

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