New insights into the immunopathogenesis of systemic lupus erythematosus

被引：948

作者：

Tsokos, George C. ^{[1
]}

Lo, Mindy S. ^{[2
]}

Reis, Patricia Costa ^{[3
]}

Sullivan, Kathleen E. ^{[4
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Rheumatol, 110 Francis St, Boston, MA 02215 USA

[2] Harvard Med Sch, Boston Childrens Hosp, Div Immunol, 300 Longwood Ave, Boston, MA 02115 USA

[3] Univ Lisbon, Lisbon Med Sch, Dept Pediat, Hosp Santa Maria, Ave Prof Egas Moniz, P-1649035 Lisbon, Portugal

[4] Univ Penn, Perelman Sch Med, Childrens Hosp Philadelphia, Div Allergy & Immunol, 3615 Civ Ctr Blvd, Philadelphia, PA 19104 USA

来源：

NATURE REVIEWS RHEUMATOLOGY | 2016年 / 12卷 / 12期

关键词：

AICARDI-GOUTIERES SYNDROME; CD4(+) T-CELLS; HISTONE DEACETYLASE INHIBITORS; CHRONIC GRANULOMATOUS-DISEASE; PLASMACYTOID DENDRITIC CELLS; FAMILIAL CHILBLAIN LUPUS; NAIVE CD4+T CELLS; B-CELLS; AUTOANTIBODY PRODUCTION; INTERFERON-ALPHA;

D O I：

10.1038/nrrheum.2016.186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes contributions from the environment, stochastic factors, and genetic susceptibility. Great gains have been made in understanding SLE through the use of genetic variant identification, mouse models, gene expression studies, and epigenetic analyses. Collectively, these studies support the concept that defective clearance of immune complexes and biological waste (such as apoptotic cells), neutrophil extracellular traps, nucleic acid sensing, lymphocyte signalling, and interferon production pathways are all central to loss of tolerance and tissue damage. Increased understanding of the pathogenesis of SLE is driving a renewed interest in targeted therapy, and researchers are now on the verge of developing targeted immunotherapy directed at treating either specific organ system involvement or specific subsets of patients with SLE. Accordingly, this Review places these insights within the context of our current understanding of the pathogenesis of SLE and highlights pathways that are ripe for therapeutic targeting.

引用

页码：716 / 730

页数：15

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