Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer

被引:11
作者
Raouf, Samar M. Abdel [1 ]
Ibrahim, Taiseer R. [1 ]
Abdelaziz, Lobna A. [2 ]
Farid, Mohamed, I [3 ]
Mohamed, Salem Y. [4 ]
机构
[1] Zagazig Univ, Fac Med, Pathol Dept, Zagazig, Egypt
[2] Zagazig Univ, Fac Med, Clin Oncol & Nucl Med Dept, Zagazig, Egypt
[3] Zagazig Univ, Fac Med, Gen Surg Dept, Zagazig, Egypt
[4] Zagazig Univ, Fac Med, Internal Med Dept, Gastroenterol & Hepatol Unit, Zagazig, Egypt
关键词
Twist1; EZH2; Colorectal cancer; Immunohistochemistry; HUMAN COLORECTAL-CANCER; METHYLATION; INVASION; TARGET;
D O I
10.1007/s12029-019-00344-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Colorectal carcinoma (CRC) is the third most common human cancer. Twist, a basic helix-loop-helix (bHLH) transcription factor, is an epithelial-mesenchymal transition ((EMT) inducer that has been involved in carcinogenesis and chemoresistance. Also, the enhancer of Zeste homolologue2 (EZH2), a member of the polycomb group of genes, had been associated with poor prognosis in several malignancies. Objective To evaluate the expression of Twist1 and EZH2 in colon carcinoma in Egyptian patients and its relation to clinicopathological parameters, prognosis, and survival. Methods Twist1 and EZH2 expressions were evaluated immunohistochemically in 50 cases of colorectal tumors (12 colon adenomas and 38 colon carcinomas) and 20 samples from normal colonic mucosa. Results The expression of Twist1 and EZH2 was significantly higher in colon adenoma and carcinoma than that in normal colonic mucosa (P< 0.05). Twist1 and EZH2 expressions were associated with decreased tumor differentiation, advanced stage, and lymph node metastasis. Twist1 and EZH2 expressions were significantly related to 3-year disease-free survival (P= 0.005 and 0.002 respectively) and 3-year overall survival (P= 0.045 and 0.039, respectively). Conclusions Twist1 and EZH2 may serve as prognostic predictors for colon carcinoma and may have a potential role as therapeutic targets in patients with colon carcinoma in the future.
引用
收藏
页码:90 / 98
页数:9
相关论文
共 35 条
  • [1] Abdelrahman AE, 2017, TURK J PATHOL, V33, P198, DOI 10.5146/tjpath.2016.01392
  • [2] [Anonymous], 2015, MENOUFIA MED J
  • [3] EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    Bachmann, IM
    Halvorsen, OJ
    Collett, K
    Stefansson, IM
    Straume, O
    Haukaas, SA
    Salvesen, HB
    Otte, AP
    Akslen, LA
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (02) : 268 - 273
  • [4] Byrd D.R., 2010, AJCC cancer staging manual, V649
  • [5] Twist-1 Induces Ezh2 Recruitment Regulating Histone Methylation along the Ink4A/Arf Locus in Mesenchymal Stem Cells
    Cakouros, Dimitrios
    Isenmann, Sandra
    Cooper, Lachlan
    Zannettino, Andrew
    Anderson, Peter
    Glackin, Carlotta
    Gronthos, Stan
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2012, 32 (08) : 1433 - 1441
  • [6] Expression of EZH2 is associated with poor outcome in colorectal cancer
    Chen, Zhuanpeng
    Yang, Ping
    Li, Wanglin
    He, Feng
    Wei, Jianchang
    Zhang, Tong
    Zhong, Junbin
    Chen, Huacui
    Cao, Jie
    [J]. ONCOLOGY LETTERS, 2018, 15 (03) : 2953 - 2961
  • [7] Chou RH, 2011, AM J TRANSL RES, V3, P243
  • [8] Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    Ferlay, Jacques
    Shin, Hai-Rim
    Bray, Freddie
    Forman, David
    Mathers, Colin
    Parkin, Donald Maxwell
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (12) : 2893 - 2917
  • [9] EZH2 Depletion Blocks the Proliferation of Colon Cancer Cells
    Fussbroich, Bettina
    Wagener, Nina
    Macher-Goeppinger, Stephan
    Benner, Axel
    Faelth, Maria
    Sueltmann, Holger
    Holzer, Angela
    Hoppe-Seyler, Karin
    Hoppe-Seyler, Felix
    [J]. PLOS ONE, 2011, 6 (07):
  • [10] TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer
    Galvan, Jose A.
    Helbling, Melina
    Koelzer, Viktor H.
    Tschan, Mario P.
    Berger, Martin D.
    Haedrich, Marion
    Schnueriger, Beat
    Karamitopoulou, Eva
    Dawson, Heather
    Inderbitzin, Daniel
    Lugli, Alessandro
    Zlobec, Inti
    [J]. ONCOTARGET, 2015, 6 (02) : 874 - 885