Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer

被引：14
作者：
Raouf, Samar M. Abdel [1 ]
Ibrahim, Taiseer R. [1 ]
Abdelaziz, Lobna A. [2 ]
Farid, Mohamed, I [3 ]
Mohamed, Salem Y. [4 ]
机构：
[1] Zagazig Univ, Fac Med, Pathol Dept, Zagazig, Egypt
[2] Zagazig Univ, Fac Med, Clin Oncol & Nucl Med Dept, Zagazig, Egypt
[3] Zagazig Univ, Fac Med, Gen Surg Dept, Zagazig, Egypt
[4] Zagazig Univ, Fac Med, Internal Med Dept, Gastroenterol & Hepatol Unit, Zagazig, Egypt
来源：
JOURNAL OF GASTROINTESTINAL CANCER | 2021年 / 52卷 / 01期
关键词：
Twist1; EZH2; Colorectal cancer; Immunohistochemistry; HUMAN COLORECTAL-CANCER; METHYLATION; INVASION; TARGET;
D O I：
10.1007/s12029-019-00344-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background Colorectal carcinoma (CRC) is the third most common human cancer. Twist, a basic helix-loop-helix (bHLH) transcription factor, is an epithelial-mesenchymal transition ((EMT) inducer that has been involved in carcinogenesis and chemoresistance. Also, the enhancer of Zeste homolologue2 (EZH2), a member of the polycomb group of genes, had been associated with poor prognosis in several malignancies. Objective To evaluate the expression of Twist1 and EZH2 in colon carcinoma in Egyptian patients and its relation to clinicopathological parameters, prognosis, and survival. Methods Twist1 and EZH2 expressions were evaluated immunohistochemically in 50 cases of colorectal tumors (12 colon adenomas and 38 colon carcinomas) and 20 samples from normal colonic mucosa. Results The expression of Twist1 and EZH2 was significantly higher in colon adenoma and carcinoma than that in normal colonic mucosa (P< 0.05). Twist1 and EZH2 expressions were associated with decreased tumor differentiation, advanced stage, and lymph node metastasis. Twist1 and EZH2 expressions were significantly related to 3-year disease-free survival (P= 0.005 and 0.002 respectively) and 3-year overall survival (P= 0.045 and 0.039, respectively). Conclusions Twist1 and EZH2 may serve as prognostic predictors for colon carcinoma and may have a potential role as therapeutic targets in patients with colon carcinoma in the future.
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收藏
页码：90 / 98
页数：9
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