Twist1;
EZH2;
Colorectal cancer;
Immunohistochemistry;
HUMAN COLORECTAL-CANCER;
METHYLATION;
INVASION;
TARGET;
D O I:
10.1007/s12029-019-00344-4
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Background Colorectal carcinoma (CRC) is the third most common human cancer. Twist, a basic helix-loop-helix (bHLH) transcription factor, is an epithelial-mesenchymal transition ((EMT) inducer that has been involved in carcinogenesis and chemoresistance. Also, the enhancer of Zeste homolologue2 (EZH2), a member of the polycomb group of genes, had been associated with poor prognosis in several malignancies. Objective To evaluate the expression of Twist1 and EZH2 in colon carcinoma in Egyptian patients and its relation to clinicopathological parameters, prognosis, and survival. Methods Twist1 and EZH2 expressions were evaluated immunohistochemically in 50 cases of colorectal tumors (12 colon adenomas and 38 colon carcinomas) and 20 samples from normal colonic mucosa. Results The expression of Twist1 and EZH2 was significantly higher in colon adenoma and carcinoma than that in normal colonic mucosa (P< 0.05). Twist1 and EZH2 expressions were associated with decreased tumor differentiation, advanced stage, and lymph node metastasis. Twist1 and EZH2 expressions were significantly related to 3-year disease-free survival (P= 0.005 and 0.002 respectively) and 3-year overall survival (P= 0.045 and 0.039, respectively). Conclusions Twist1 and EZH2 may serve as prognostic predictors for colon carcinoma and may have a potential role as therapeutic targets in patients with colon carcinoma in the future.
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页码:90 / 98
页数:9
相关论文
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[1]
Abdelrahman AE, 2017, TURK J PATHOL, V33, P198, DOI 10.5146/tjpath.2016.01392
机构:
Univ Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Cakouros, Dimitrios
Isenmann, Sandra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Isenmann, Sandra
Cooper, Lachlan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Cooper, Lachlan
论文数: 引用数:
h-index:
机构:
Zannettino, Andrew
Anderson, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Womens & Childrens Hosp, Australian Craniofacial Unit, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Anderson, Peter
Glackin, Carlotta
论文数: 0引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USAUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
机构:
Univ Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Cakouros, Dimitrios
Isenmann, Sandra
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Isenmann, Sandra
Cooper, Lachlan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Cooper, Lachlan
论文数: 引用数:
h-index:
机构:
Zannettino, Andrew
Anderson, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Womens & Childrens Hosp, Australian Craniofacial Unit, Adelaide, SA, AustraliaUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia
Anderson, Peter
Glackin, Carlotta
论文数: 0引用数: 0
h-index: 0
机构:
City Hope Natl Med Ctr, Beckman Res Inst, Duarte, CA 91010 USAUniv Adelaide, SA Pathol, Dept Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA, Australia