Pharmacodynamics and pharmacokinetics of antibacterial drugs in the management of febrile neutropenia

被引：66
作者：
Lortholary, Olivier [3 ]
Lefort, Agnes [4 ]
Tod, Michel [5 ,6 ]
Chomat, Anne-Marie [3 ]
Darras-Joly, Clemence [7 ]
Cordonnier, Catherine [1 ,2 ]
机构：
[1] Hop Henri Mondor, AP HP, Dept Haematol, F-94000 Creteil, France
[2] Univ Paris 12, Creteil, France
[3] Univ Paris 05, Hop Necker Enfants Malad, Ctr Infectiol Necker Pasteur, Dept Infect & Trop Dis, Paris, France
[4] Hop Beaujon, Dept Internal Med, Clichy, France
[5] Hop Cochin, Dept Pharm, F-75674 Paris, France
[6] Univ Lyon, EA Team 3738, Lyon, France
[7] Hop Charles Nicolle, Dept Infect & Trop dis, Rouen, France
来源：
LANCET INFECTIOUS DISEASES | 2008年 / 8卷 / 10期
关键词：
D O I：
10.1016/S1473-3099(08)70228-7
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We review experimental and clinical data on the pharmacokinetics and pharmacodynamics of antibacterial drugs in febrile neutropenic hosts. Since major pharmacokinetic changes have been reported for various classes of antibiotics in these patients, we advocate the need for adequate initial dosing regimens in all cases. Monitoring drug serum concentrations is mandatory for aminoglycosides and glycopeptides, and special attention should be paid to the dosing frequency of the short half-life beta-lactams to optimise the management of febrile neutropenia, especially in patients with severe sepsis.
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收藏
页码：612 / 620
页数：9
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