Matrix metalloproteinases

被引：228
作者：
Parsons, SL [1 ]
Watson, SA [1 ]
Brown, PD [1 ]
Collins, HM [1 ]
Steele, RJC [1 ]
机构：
[1] BRITISH BIOTECH PHARMACEUT LTD,OXFORD,ENGLAND
来源：
BRITISH JOURNAL OF SURGERY | 1997年 / 84卷 / 02期
关键词：
D O I：
10.1002/bjs.1800840206
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Background The matrix metalloproteinases (MMPs) have a role in gastrointestinal malignancy. This role is reviewed, with particular reference to the gelatinase subgroup of enzymes. Methods All relevant papers derived from the Medline and Enbase databases between 1984 and early 1996 were reviewed. Result and Conclusion There is now strong evidence that MMPs play a major role in tumour invasion and metastasis. The development of MMP inhibitors may lead to important new treatment for the control of malignant disease.
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页码：160 / 166
页数：7
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