Association of Serum Irisin Concentrations with Presence and Severity of Coronary Artery Disease

被引：54
作者：
Deng, Wen [1 ]
机构：
[1] Yantai Hill Hosp, Dept Cardiovasc Med, Yantai, Shandong, Peoples R China
来源：
MEDICAL SCIENCE MONITOR | 2016年 / 22卷
关键词：
Coronary Artery Disease; Receptors; Cytokine; Severity of Illness Index; IMPROVES ENDOTHELIAL FUNCTION; INTIMA-MEDIA-THICKNESS; INSULIN-RESISTANCE; ATHEROSCLEROSIS; MYOKINE; PATHWAY; OBESITY; TYPE-2; MICE; FAT;
D O I：
10.12659/MSM.897376
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Irisin, an exercise-induced myokine, is closely correlated with obesity and body mass index. Obesity is one risk factor of coronary artery disease (CAD). Therefore, the present study aimed to determine if serum irisin concentrations are correlated with the presence and severity of CAD. Material/Methods: Serum irisin concentrations were determined in 350 patients with CAD and in 214 healthy subjects. The severity of CAD was assessed by coronary atherosclerosis index (CAI). Results: Serum irisin concentrations were significantly lower in CAD patients compared with healthy controls. Multivariable logistic regression analysis revealed that serum irisin concentrations were an independent determinant of the presence of CAD. In addition, Pearson correlation analysis showed that serum irisin concentrations were negatively correlated with CAI in CAD patients. Conclusions: Decreased serum irisin concentrations may be associated with the presence and severity of CAD.
引用
收藏
页码：4193 / 4197
页数：5
相关论文
共 18 条
[1]   Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events [J].
Aronis, K. N. ;
Moreno, M. ;
Polyzos, S. A. ;
Moreno-Navarrete, J. M. ;
Ricart, W. ;
Delgado, E. ;
de la Hera, J. ;
Sahin-Efe, A. ;
Chamberland, J. P. ;
Berman, R. ;
Spiro, A., III ;
Vokonas, P. ;
Fernandez-Real, J. M. ;
Mantzoros, C. S. .
INTERNATIONAL JOURNAL OF OBESITY, 2015, 39 (01) :156-161
[2]   A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis [J].
Bostroem, Pontus ;
Wu, Jun ;
Jedrychowski, Mark P. ;
Korde, Anisha ;
Ye, Li ;
Lo, James C. ;
Rasbach, Kyle A. ;
Bostroem, Elisabeth Almer ;
Choi, Jang Hyun ;
Long, Jonathan Z. ;
Kajimura, Shingo ;
Zingaretti, Maria Cristina ;
Vind, Birgitte F. ;
Tu, Hua ;
Cinti, Saverio ;
Hojlund, Kurt ;
Gygi, Steven P. ;
Spiegelman, Bruce M. .
NATURE, 2012, 481 (7382) :463-U72
[3]   Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes [J].
Gao, Shanshan ;
Li, Fangmin ;
Li, Huimin ;
Huang, Yibing ;
Liu, Yu ;
Chen, Yuxin .
PLOS ONE, 2016, 11 (01)
[4]   Irisin improves endothelial function in obese mice through the AMPK-eNOS pathway [J].
Han, Fang ;
Zhang, Shuxian ;
Hou, Ningning ;
Wang, Di ;
Sun, Xiaodong .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2015, 309 (09) :H1501-H1508
[5]   Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients [J].
Lee, Mi Jung ;
Lee, Sul A. ;
Nam, Bo Young ;
Park, Sungha ;
Lee, Sang-Hak ;
Ryu, Han Jak ;
Kwon, Young Eun ;
Kim, Yung Ly ;
Park, Kyoung Sook ;
Oh, Hyung Jung ;
Park, Jung Tak ;
Han, Seung Hyeok ;
Ryu, Dong-Ryeol ;
Kang, Shin-Wook ;
Yoo, Tae-Hyun .
ATHEROSCLEROSIS, 2015, 242 (02) :476-482
[6]   Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans [J].
Lee, Paul ;
Linderman, Joyce D. ;
Smith, Sheila ;
Brychta, Robert J. ;
Wang, Juan ;
Idelson, Christopher ;
Perron, Rachel M. ;
Werner, Charlotte D. ;
Phan, Giao Q. ;
Kammula, Udai S. ;
Kebebew, Electron ;
Pacak, Karel ;
Chen, Kong Y. ;
Celi, Francesco S. .
CELL METABOLISM, 2014, 19 (02) :302-309
[7]   Prospects for cardiovascular research [J].
Lefkowitz, RJ ;
Willerson, JT .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (05) :581-587
[8]   Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice [J].
Lu, Junyan ;
Xiang, Guangda ;
Liu, Min ;
Mei, Wen ;
Xiang, Lin ;
Dong, Jing .
ATHEROSCLEROSIS, 2015, 243 (02) :438-448
[9]   Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance [J].
Mara Moreno-Navarrete, Jose ;
Ortega, Francisco ;
Serrano, Marta ;
Guerra, Ester ;
Pardo, Gerard ;
Tinahones, Francisco ;
Ricart, Wifredo ;
Manuel Fernandez-Real, Jose .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (04) :E769-E778
[10]  
Nikolajevic-Starcevic J, 2014, INT ANGIOL, V33, P434
12