Alpha-Lipoic Acid Protects against Indomethacin-Induced Gastric Oxidative Toxicity by Modulating Antioxidant System

被引：36

作者：

Kaplan, Kursat Ali ^{[2
]}

Odabasoglu, Fehmi ^{[2
]}

Halici, Zekai ^{[3
]}

Halici, Mesut ^{[4
]}

Cadirci, Elif ^{[5
]}

Atalay, Fadime ^{[2
]}

Aydin, Ozlem ^{[2
]}

Cakir, Ahmet ^{[1
]}

机构：

[1] Kilis 7 Aralik Univ, Fac Sci & Art, Dept Chem, TR-79000 Kilis, Turkey

[2] Ataturk Univ, Dept Biochem, Fac Pharm, TR-25240 Erzurum, Turkey

[3] Ataturk Univ, Dept Pharmacol, Fac Med, TR-25240 Erzurum, Turkey

[4] Ataturk Univ, Fac Vet, Dept Biochem, TR-25240 Erzurum, Turkey

[5] Ataturk Univ, Fac Pharm, Dept Pharmacol, TR-25240 Erzurum, Turkey

来源：

JOURNAL OF FOOD SCIENCE | 2012年 / 77卷 / 11期

关键词：

alpha-lipoic acid; antioxidant enzymes; indomethacin; myeloperoxidase; LIPID-PEROXIDATION; MUCOSAL DAMAGE; INJURY; RATS; ERYTHROPOIETIN; INHIBITION; STRESS; TISSUE; CELLS; ASSAY;

D O I：

10.1111/j.1750-3841.2012.02920.x

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Gastroprotective effects of alpha-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems.

引用

页码：H224 / H230

页数：7

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