Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation

被引：119

作者：

Amroyan, E

Gabrielian, E

Panossian, A

Wikman, G

Wagner, H

机构：

[1] Yerevan State Med Univ, Yerevan, Armenia

[2] Swedish Herbal Inst, Gothenburg, Sweden

[3] Univ Munich, Inst Pharmaceut Biol, D-8000 Munich, Germany

来源：

PHYTOMEDICINE | 1999年 / 6卷 / 01期

关键词：

Andrographis paniculata; andrographolide; inhibition of PAF induced human blood plateled aggregation; eicosanoids;

D O I：

10.1016/S0944-7113(99)80031-2

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Andrographolide, an active principle of the Chinese drug Andrographis paniculata, used for prevention and treatment of common cold in Scandinavia and known as an antiinflammatory, antiviral, antithrombotic, hypotensive and antiatherosclerotic drug, was investigated for its suggested influence on the biosynthesis of eicosanoids and the platelet-activating factor (PAF). Whereas in isolated human polymorphonuclear leukocytes (PMNL) no influence on the biosynthesis was found, it could be shown that andrographolide inhibits PAF-induced human blood platelet aggregation in a dose dependent manner (IC50 similar to 5 mu M). These results indicate that andrographolide has a mechanism of action different from that of non-steroidal antiinflammatory drugs (NSAID) and most likely associated with the cardiovascular and antithrombotic activity described of Andrographis paniculata.

引用

页码：27 / 31

页数：5

共 29 条

[1]

Bensky D., 1993, CHINESE HERBAL MED M, P95

[2]

Borhanuddin M, 1994, Bangladesh Med Res Counc Bull, V20, P24

[3]

BORN GVR, 1962, NATURE, V194, P926

[4]

BOYUM A, 1987, SCAND J IMMUNOL, V5, P9

[5]

Braquet P, 1985, BLOOD VESSELS, V16, P558, DOI DOI 10.2491/jjsth1970.16.558

[6] Prevention of common colds with Andrographis paniculata dried extract. A pilot double blind trial [J].

Caceres, DD ;

Hancke, JL ;

Burgos, RA ;

Wikman, GK .

PHYTOMEDICINE, 1997, 4 (02) :101-104

[7] ANDROGRAPHOLIDE - FURTHER TRANSFORMATIONS AND STEREOCHEMICAL EVIDENCE STRUCTURE OF ISOANDROGRAPHOLIDE [J].

CAVA, MP ;

CHAN, WR ;

STEIN, RP ;

WILLIS, CR .

TETRAHEDRON, 1965, 21 (09) :2617-&

[8] ANDROGRAPHOLIDE .1. [J].

CHAKRAVARTI, D ;

CHAKRAVARTI, RN .

JOURNAL OF THE CHEMICAL SOCIETY, 1952, (MAY) :1697-1700

[9]

Chang HM, 1987, PHARM APPL CHINESE M, V2, P918

[10]

CHANG RS, 1991, P SOC EXP BIOL MED, V197, P59

← 1 2 3 →