Notch and PI3K: how is the road traveled?

被引:16
作者
Bailis, Will [1 ]
Pear, Warren S. [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
关键词
T-ALL; LEUKEMIA; EXPRESSION; PATHWAY; ROLES; PTEN;
D O I
10.1182/blood-2012-06-435099
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1349 / 1350
页数:2
相关论文
共 10 条
  • [1] Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia
    Chan, Steven M.
    Weng, Andrew P.
    Tibshirani, Robert
    Aster, Jon C.
    Utz, Paul J.
    [J]. BLOOD, 2007, 110 (01) : 278 - 286
  • [2] Targeting the Notch1 and mTOR pathways in a mouse T-ALL model
    Cullion, Kathleen
    Draheim, Kyle M.
    Hermance, Nicole
    Tammam, Jennifer
    Sharma, Vishva M.
    Ware, Christopher
    Nikov, George
    Krishnamoorthy, Veena
    Majumder, Pradip K.
    Kelliher, Michelle A.
    [J]. BLOOD, 2009, 113 (24) : 6172 - 6181
  • [3] CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7Rα gene expression in early human thymopoiesis and leukemia
    Gonzalez-Garcia, Sara
    Garcia-Peydro, Marina
    Martin-Gayo, Enrique
    Ballestar, Esteban
    Esteller, Manel
    Bornstein, Rafael
    Luis de la Pompa, Jose
    Ferrando, Adolfo A.
    Toribio, Maria L.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (04) : 779 - 791
  • [4] Critical roles of the PI3K/Akt signaling pathway in T cell development
    Juntilla, Marisa A.
    Koretzky, Guy A.
    [J]. IMMUNOLOGY LETTERS, 2008, 116 (02) : 104 - 110
  • [5] Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
    Lee, Keunwook
    Nam, Ki Taek
    Cho, Sung Hoon
    Gudapati, Prathyusha
    Hwang, Yoonha
    Park, Do-Sim
    Potter, Ross
    Chen, Jin
    Volanakis, Emmanuel
    Boothby, Mark
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (04) : 713 - 728
  • [6] High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling
    Medyouf, Hind
    Gusscott, Samuel
    Wang, Hongfang
    Tseng, Jen-Chieh
    Wai, Carol
    Nemirovsky, Oksana
    Trumpp, Andreas
    Pflumio, Francoise
    Carboni, Joan
    Gottardis, Marco
    Pollak, Michael
    Kung, Andrew L.
    Aster, Jon C.
    Holzenberger, Martin
    Weng, Andrew P.
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (09) : 1809 - 1822
  • [7] Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss
    Medyouf, Hind
    Gao, Xiuhua
    Armstrong, Florence
    Gusscott, Samuel
    Liu, Qing
    Gedman, Amanda Larson
    Matherly, Larry H.
    Schultz, Kirk R.
    Pflumio, Francoise
    You, Mingjian James
    Weng, Andrew P.
    [J]. BLOOD, 2010, 115 (06) : 1175 - 1184
  • [8] Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
    Palomero, Teresa
    Sulis, Maria Luisa
    Cortina, Maria
    Real, Pedro J.
    Barnes, Kelly
    Ciofani, Maria
    Caparros, Esther
    Buteau, Jean
    Brown, Kristy
    Perkins, Sherrie L.
    Bhagat, Govind
    Agarwal, Archana M.
    Basso, Giuseppe
    Castillo, Mireia
    Nagase, Satoru
    Cordon-Cardo, Carlos
    Parsons, Ramon
    Zuniga-Pflucker, Juan Carlos
    Dominguez, Maria
    Ferrando, Adolfo A.
    [J]. NATURE MEDICINE, 2007, 13 (10) : 1203 - 1210
  • [9] Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation
    Wendorff, Agnieszka A.
    Koch, Ute
    Wunderlich, F. Thomas
    Wirth, Silvia
    Dubey, Christelle
    Bruening, Jens C.
    MacDonald, H. Robson
    Radtke, Freddy
    [J]. IMMUNITY, 2010, 33 (05) : 671 - 684
  • [10] HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes
    Wong, Gladys W.
    Knowles, Gisele C.
    Mak, Tak W.
    Ferrando, Adolfo A.
    Zuniga-Pfluecker, Juan Carlos
    [J]. BLOOD, 2012, 120 (07) : 1439 - 1448