Notch and PI3K: how is the road traveled?

被引:16
作者
Bailis, Will [1 ]
Pear, Warren S. [1 ]
机构
[1] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
关键词
T-ALL; LEUKEMIA; EXPRESSION; PATHWAY; ROLES; PTEN;
D O I
10.1182/blood-2012-06-435099
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1349 / 1350
页数:2
相关论文
共 10 条
[1]   Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia [J].
Chan, Steven M. ;
Weng, Andrew P. ;
Tibshirani, Robert ;
Aster, Jon C. ;
Utz, Paul J. .
BLOOD, 2007, 110 (01) :278-286
[2]   Targeting the Notch1 and mTOR pathways in a mouse T-ALL model [J].
Cullion, Kathleen ;
Draheim, Kyle M. ;
Hermance, Nicole ;
Tammam, Jennifer ;
Sharma, Vishva M. ;
Ware, Christopher ;
Nikov, George ;
Krishnamoorthy, Veena ;
Majumder, Pradip K. ;
Kelliher, Michelle A. .
BLOOD, 2009, 113 (24) :6172-6181
[3]   CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7Rα gene expression in early human thymopoiesis and leukemia [J].
Gonzalez-Garcia, Sara ;
Garcia-Peydro, Marina ;
Martin-Gayo, Enrique ;
Ballestar, Esteban ;
Esteller, Manel ;
Bornstein, Rafael ;
Luis de la Pompa, Jose ;
Ferrando, Adolfo A. ;
Toribio, Maria L. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (04) :779-791
[4]   Critical roles of the PI3K/Akt signaling pathway in T cell development [J].
Juntilla, Marisa A. ;
Koretzky, Guy A. .
IMMUNOLOGY LETTERS, 2008, 116 (02) :104-110
[5]   Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia [J].
Lee, Keunwook ;
Nam, Ki Taek ;
Cho, Sung Hoon ;
Gudapati, Prathyusha ;
Hwang, Yoonha ;
Park, Do-Sim ;
Potter, Ross ;
Chen, Jin ;
Volanakis, Emmanuel ;
Boothby, Mark .
JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (04) :713-728
[6]   High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling [J].
Medyouf, Hind ;
Gusscott, Samuel ;
Wang, Hongfang ;
Tseng, Jen-Chieh ;
Wai, Carol ;
Nemirovsky, Oksana ;
Trumpp, Andreas ;
Pflumio, Francoise ;
Carboni, Joan ;
Gottardis, Marco ;
Pollak, Michael ;
Kung, Andrew L. ;
Aster, Jon C. ;
Holzenberger, Martin ;
Weng, Andrew P. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (09) :1809-1822
[7]   Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss [J].
Medyouf, Hind ;
Gao, Xiuhua ;
Armstrong, Florence ;
Gusscott, Samuel ;
Liu, Qing ;
Gedman, Amanda Larson ;
Matherly, Larry H. ;
Schultz, Kirk R. ;
Pflumio, Francoise ;
You, Mingjian James ;
Weng, Andrew P. .
BLOOD, 2010, 115 (06) :1175-1184
[8]   Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia [J].
Palomero, Teresa ;
Sulis, Maria Luisa ;
Cortina, Maria ;
Real, Pedro J. ;
Barnes, Kelly ;
Ciofani, Maria ;
Caparros, Esther ;
Buteau, Jean ;
Brown, Kristy ;
Perkins, Sherrie L. ;
Bhagat, Govind ;
Agarwal, Archana M. ;
Basso, Giuseppe ;
Castillo, Mireia ;
Nagase, Satoru ;
Cordon-Cardo, Carlos ;
Parsons, Ramon ;
Zuniga-Pflucker, Juan Carlos ;
Dominguez, Maria ;
Ferrando, Adolfo A. .
NATURE MEDICINE, 2007, 13 (10) :1203-1210
[9]   Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation [J].
Wendorff, Agnieszka A. ;
Koch, Ute ;
Wunderlich, F. Thomas ;
Wirth, Silvia ;
Dubey, Christelle ;
Bruening, Jens C. ;
MacDonald, H. Robson ;
Radtke, Freddy .
IMMUNITY, 2010, 33 (05) :671-684
[10]   HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes [J].
Wong, Gladys W. ;
Knowles, Gisele C. ;
Mak, Tak W. ;
Ferrando, Adolfo A. ;
Zuniga-Pfluecker, Juan Carlos .
BLOOD, 2012, 120 (07) :1439-1448