New roles for pyruvate kinase M2: working out the Warburg effect

被引：57

作者：

Ferguson, Emily C. ^{[1
]}

Rathmell, Jeffrey C. ^{[1
,2
,3
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Sarah W Stedman Ctr Nutr & Metab, Durham, NC 27710 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2008年 / 33卷 / 08期

关键词：

D O I：

10.1016/j.tibs.2008.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The origins and role of the Warburg effect have remained uncertain for many years. Two recent studies demonstrate that an embryonic- and cancer-cell-specific isoform of the enzyme pyruvate kinase M2 (PKM2) is regulated by binding to phospho-tyrosine motifs and promotes increased cell growth and tumor development. PKM2 enhances the use of glycolytic intermediates for macromolecular biosynthesis and tumor growth. These findings illustrate the distinct advantages of this metabolic phenotype in cancer cell growth.

引用

页码：359 / 362

页数：4

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