Candidate genes and new therapeutic options for osteoporosis

被引：0

作者：

Obermayer-Pietsch, B. ^{[1
,2
]}

机构：

[1] Med Univ Graz, Klin Abt, Univ Klin Innere Med, A-8036 Graz, Austria

[2] Med Univ Graz, Lab Endokrinol & Stoffwechsel, A-8036 Graz, Austria

来源：

OSTEOLOGIE | 2011年 / 20卷 / 03期

关键词：

Candidate gene; polymorphism; osteoporosis; GWAS; GENOME-WIDE ASSOCIATION; BONE-FORMATION; POSTMENOPAUSAL WOMEN; INHIBITOR; DENSITY; POLYMORPHISM; METAANALYSIS; DICKKOPF-1; FRACTURES; PREVENTS;

D O I：

暂无

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The genetic background of osteoporosis has long been investigated. Several genetic loci have been identified, which have already been shown to be associated with an increased risk for low bone mineral density. Critical bone pathways out of these genes have been used to develop therapeutic applications. Based on huge genome-wide association studies, new candidate genes for bone mineral density and osteoporotic fractures have now been reported. They will not only shed light on the complex pathophysiological pathways of osteoporosis, but might also be the basis for the development of new therapeutic drugs for osteoporosis.

引用

页码：227 / 232

页数：6

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