Effects of selected South African plant extracts on haemolysis and coagulation

被引：14
|
作者：
Cordier, Werner [1 ]
Cromarty, Allan D. [1 ]
Botha, Elsabie [2 ]
Steenkamp, Vanessa [1 ]
机构：
[1] Univ Pretoria, Dept Pharmacol, Fac Hlth Sci, ZA-0001 Pretoria, South Africa
[2] Natl Hlth Lab Serv, Dept Haematol, Pretoria, South Africa
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 2012年 / 31卷 / 03期
关键词：
anticoagulant; coumarins; haemolysis; herbal; plant extracts; salicylic acid; MEDICINAL-PLANTS; INHIBITION; MECHANISM; PROPERTY; VENDA;
D O I：
10.1177/0960327111398675
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The use of herbal preparations for staunching blood flow and reducing the risk of vascular thrombosis is common worldwide. In this study, aqueous and methanolic extracts of plants used to treat blood-associated complaints were investigated to determine their effects on red blood cell haemolysis and coagulation. The extent of haemolysis was determined spectrophotometrically. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) as indicators of coagulation rate were determined using a coagulatometer. All of the plant extracts tested had a significant effect on coagulation time, prolonging the aPTT. Cassia petersiana had the greatest prolonging effect on PT compared to the control, phosphate buffered saline (PBS). As all of the herbal extracts tested had a delaying effect on coagulation, patients using herbal/plant therapies should be cautioned to stop their medication before surgery.
引用
收藏
页码：250 / 257
页数：8
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