MEMS Oxygen Transport Device for Islet Transplantation in the Subcutaneous Site

被引：0
|
作者：
Kang, Dongyang [1 ]
Komatsu, Hirotake [2 ]
Lin, Henry [2 ]
Cook, Colin A. [1 ]
Tai, Yu-Chong [1 ]
Mullen, Yoko [2 ]
Kandeel, Fouad R. [2 ]
机构：
[1] CALTECH, Dept Elect Engn, Pasadena, CA 91125 USA
[2] City Hope Natl Med Ctr, Beckman Res Inst, Dept Diabet & Metab Res, Duarte, CA USA
来源：
2016 IEEE 11TH ANNUAL INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (NEMS) | 2016年
关键词：
type; 1; diabetes; islet transplantation; hypoxia; MEMS oxygen transport device; HYDROGEL; CELLS;
D O I：
暂无
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
This paper presents a new MEMS approach of maintaining islet oxygenation for subcutaneous islet transplantation therapy of type 1 diabetes by engineering a MEMS oxygen transport device. A device is designed and fabricated. Bench-top testing and computational modeling of the device have demonstrated that it would provide sufficient oxygen to prevent hypoxia-induced islet death and maintain the functional metabolic activity of glucose-simulated insulin secretion for islets transplanted subcutaneously.
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页数：5
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