Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview

被引：131

作者：

Averianova, Liudmila A. ^{[1
]}

Balabanova, Larissa A. ^{[1
,2
]}

Son, Oksana M. ^{[1
,3
]}

Podvolotskaya, Anna B. ^{[1
,3
]}

Tekutyeva, Liudmila A. ^{[1
,3
]}

机构：

[1] Far Eastern Fed Univ, Sch Econ & Management, Dept Bioecon & Food Secur, Vladivostok, Russia

[2] Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Marine Biochem Lab, Vladivostok, Russia

[3] ARNIKA, Terr PDA Nadezhdinskaya, Primorsky Krai, Russia

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 8卷

关键词：

riboflavin; vitamin B2; genetically modified microorganisms; food; feed additive; metabolic engineering; RECOMBINANT BACILLUS-SUBTILIS; LACTIC-ACID BACTERIA; ASHBYA-GOSSYPII; LACTOCOCCUS-LACTIS; MOLECULAR CHARACTERIZATION; STRESS-RESPONSE; CANDIDA-FAMATA; BIOSYNTHESIS; OPTIMIZATION; PATHWAY;

D O I：

10.3389/fbioe.2020.570828

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Riboflavin is a crucial micronutrient that is a precursor to coenzymes flavin mononucleotide and flavin adenine dinucleotide, and it is required for biochemical reactions in all living cells. For decades, one of the most important applications of riboflavin has been its global use as an animal and human nutritional supplement. Being well-informed of the latest research on riboflavin production via the fermentation process is necessary for the development of new and improved microbial strains using biotechnology and metabolic engineering techniques to increase vitamin B2 yield. In this review, we describe well-known industrial microbial producers, namely, Ashbya gossypii, Bacillus subtilis, and Candida spp. and summarize their biosynthetic pathway optimizations through genetic and metabolic engineering, combined with random chemical mutagenesis and rational medium components to increase riboflavin production.

引用

页数：23

共 121 条

[1] Genetic Control of Biosynthesis and Transport of Riboflavin and Flavin Nucleotides and Construction of Robust Biotechnological Producers [J].