Circulating levels of IGF-I and IGFBP-3 in gastric cancer

被引：4
作者：
Altinkaynak, Konca [1 ]
Bilici, Memet [2 ]
Bakan, Nuri [3 ]
Akcay, Fatih [3 ]
机构：
[1] Reg Educ & Res Hosp, Dept Biochem, Erzurum, Turkey
[2] Ataturk Univ, Fac Med, Dept Oncol, Erzurum, Turkey
[3] Ataturk Univ, Fac Med, Dept Biochem, Erzurum, Turkey
来源：
TURKISH JOURNAL OF MEDICAL SCIENCES | 2012年 / 42卷
关键词：
Insulin-like growth factors; insulin-like growth factor-1; stage; gastric cancer; GROWTH-FACTOR-I; FACTOR-BINDING PROTEINS; COLORECTAL-CANCER; FACTOR (IGF)-I; PROSTATE-CANCER; BREAST-CANCER; PLASMA-LEVELS; FACTOR-ALPHA; INSULIN; RISK;
D O I：
10.3906/sag-1202-66
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aim: To explore the causative mechanism of gastric carcinoma and to investigate the roles of circulating IGF-I and IGFBP-3 in gastric cancer. Materials and methods: Serum IGF-I and IGFBP-3 concentrations were measured using a 2-site coated tube immunoradiometric assay. Results: Serum IGF-I and IGFBP-3 values in gastric cancer patients were significantly lower compared to those in the control group. The difference between serum IGF-I/IGFBP-3 in patients and the control group was not significant. Conclusion: The low serum IGF-I and IGFBP-3 levels detected in patients with gastric cancer could be due to decreased synthesis or increased catabolism of IGF-I or both. It could be suggested that these parameters may be important in the development and prognosis of gastric cancer.
引用
收藏
页码：1458 / 1462
页数：5
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