Toward Effective Probiotics for Autism and Other Neurodevelopmental Disorders

被引：93

作者：

Gilbert, Jack A. ^{[1
,2
]}

Krajmalnik-Brown, Rosa ^{[3
,4
]}

Porazinska, Dorota L. ^{[5
,6
]}

Weiss, Sophie J. ^{[5
,6
]}

Knight, Rob ^{[5
,6
,7
]}

机构：

[1] Argonne Natl Lab, Inst Genom & Syst Biol, Argonne, IL 60439 USA

[2] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[3] Arizona State Univ, Swette Ctr Environm Biotechnol, Biodesign Inst, Tempe, AZ 85287 USA

[4] Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA

[5] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[6] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA

[7] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

来源：

CELL | 2013年 / 155卷 / 07期

关键词：

GUT MICROBIOTA;

D O I：

10.1016/j.cell.2013.11.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hsaio and colleagues link gut microbes to autism spectrum disorders (ASD) in a mouse model. They show that ASD symptoms are triggered by compositional and structural shifts of microbes and associated metabolites, but symptoms are relieved by a Bacteroides fragilis probiotic. Thus probiotics may provide therapeutic strategies for neurodevelopmental disorders.

引用

页码：1446 / 1448

页数：3

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