Histological evidence of acute rejection after terminating anti CD40 antibody (2C10R4) treatment in GTKO.hCD46.htbm pig to baboon cardiac xenografts surviving for over one year

被引:0
|
作者
Miller, Justin [1 ]
Singh, Avneesh [1 ]
Eckhaus, Michael [2 ]
Corcoran, Philip [1 ]
Thomas, Marvin [2 ]
Lewis, Billeta [2 ]
Reimann, Keith [3 ]
Ayares, David [4 ]
Horvath, Keith [1 ]
Mohiuddin, Muhammad [1 ]
机构
[1] NHLBI, Cardiothorac Surg Res Program, NIH, Bethesda, MD 20892 USA
[2] NIH, Div Vet Resources ORS, Bethesda, MD 20892 USA
[3] Univ Massachusetts, Boston, MD USA
[4] Revivicor Inc, Blacksburg, VA USA
关键词
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
811
引用
收藏
页码:S145 / S145
页数:1
相关论文
共 9 条
  • [1] HISTOLOGICAL EVIDENCE OF ACUTE REJECTION AFTER TERMINATING ANTI CD40 ANTIBODY (2C10R4) TREATMENT IN GTKO.HCD46.HTBM PIG TO BABOON CARDIAC XENOGRAFTS SURVIVING FOR OVER ONE YEAR
    Miller, Justin
    Singh, Avneesh
    Eckhaus, Michael
    Corcoran, Philip
    Thomas, Marvin
    Lewis, Billeta
    Reimann, Keith
    Ayares, David
    Horvath, Keith
    Mohiuddin, Muhammad
    TRANSPLANTATION, 2015, 99 (11) : S236 - S236
  • [2] Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
    Muhammad M. Mohiuddin
    Avneesh K. Singh
    Philip C. Corcoran
    Marvin L. Thomas III
    Tannia Clark
    Billeta G. Lewis
    Robert F. Hoyt
    Michael Eckhaus
    Richard N. Pierson III
    Aaron J. Belli
    Eckhard Wolf
    Nikolai Klymiuk
    Carol Phelps
    Keith A. Reimann
    David Ayares
    Keith A. Horvath
    Nature Communications, 7
  • [3] Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
    Mohiuddin, Muhammad M.
    Singh, Avneesh K.
    Corcoran, Philip C.
    Thomas, Marvin L., III
    Clark, Tannia
    Lewis, Billeta G.
    Hoyt, Robert F.
    Eckhaus, Michael
    Pierson, Richard N., III
    Belli, Aaron J.
    Wolf, Eckhard
    Klymiuk, Nikolai
    Phelps, Carol
    Reimann, Keith A.
    Ayares, David
    Horvath, Keith A.
    NATURE COMMUNICATIONS, 2016, 7
  • [4] Long Term GalKO.hCD46. hTBM Pig Cardiac Xenograft Survival in Baboon May Be Dependent On Dose and Duration of Anti CD40 (2C10R4) Antibody.
    Mohiuddin, M.
    Singh, A.
    Corcoran, P.
    Hoyt, R.
    Thomas, M.
    Eckhaus, M.
    Lewis, B.
    Clark, T.
    Phelps, C.
    Ayares, D.
    Reimann, K.
    Horvath, K.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 : 415 - 415
  • [5] Long Term GalKO•hCD46. hTBM Pig Cardiac Xenograft Survival in Baboon May Be Dependent On Dose and Duration of Anti CD40 (2C10R4) Antibody.
    Mohiuddin, M.
    Singh, A.
    Corcoran, P.
    Hoyt, R.
    Thomas, M.
    Eckhaus, M.
    Lewis, B.
    Clark, T.
    Phelps, C.
    Ayares, D.
    Reimann, K.
    Horvath, K.
    TRANSPLANTATION, 2014, 98 : 415 - 415
  • [6] Critical need of continuous co-stimulation blockade with anti CD40 antibody (2C10.R4) for long-term maintenance of GTKO.HCD46.hTBM pig cardiac xenograft survival in baboons
    Mohiuddin, Muhammad
    Singh, Avneesh
    Corcoran, Philip
    Thomas, Marvin
    Lewis, Billeta
    Clark, Tannia
    Eckhaus, Michael
    Belli, Aaron
    Reimann, Keith
    Klymuik, Nikolai
    Wolf, Eckhard
    Ayares, David
    Horvath, Keith
    XENOTRANSPLANTATION, 2015, 22 : S144 - S145
  • [7] CRITICAL NEED OF CONTINUOUS CO-STIMULATION BLOCKADE WITH ANTI CD40 ANTIBODY (2C10.R4) FOR LONG-TERM MAINTENANCE OF GTKO.HCD46.HTBM PIG CARDIAC XENOGRAFT SURVIVAL IN BABOONS
    Mohiuddin, Muhammad
    Singh, Avneesh
    Corcoran, Philip
    Thomas, Marvin
    Lewis, Billeta
    Clark, Tannia
    Eckhaus, Michael
    Belli, Aaron
    Reimann, Keith
    Klymuik, Nikolai
    Wolf, Eckhard
    Ayares, David
    Horvath, Keith
    TRANSPLANTATION, 2015, 99 (11) : S236 - S236
  • [8] Over 9 months graft survival of GTKO.hCD46tg.hTMtg pig heterotopic heart xenograft in Anti CD40 (2C10) treated baboon
    Mohiuddin, Muhammad
    Singh, Avneesh
    Corcoran, Philip
    Thomas, Marvin
    Hoyt, Robert
    Lewis, Billeta
    Clark, Tannia
    Eckhaus, Michael
    Wolf, Eckhard
    Reimann, Keith
    Ayares, David
    Horvath, Keith
    XENOTRANSPLANTATION, 2013, 20 (05) : 329 - 329
  • [9] Low and tapering dose of anti CD40 (2C10 or 3A8) for 8-week duration fails to extend GTKO.hCD46Tg pig to baboon cardiac xenograft survival beyond 5 months
    Singh, Avneesh
    Corcoran, Philip
    Thomas, Marvin
    Hoyt, Robert
    Lewis, Billeta
    Clark, Tannia
    Eckhaus, Michael
    Reimann, Keith
    Ayares, David
    Horvath, Keith
    Mohiuddin, Muhammad
    XENOTRANSPLANTATION, 2013, 20 (05) : 342 - 342