Auditory hallucinations as ictal phenomena in a patient with voltage-gated potassium channel antibody-associated limbic encephalitis

被引:3
作者
Boyd, Michael [1 ]
Attarian, Hrayr [1 ]
Raizer, Jeffrey [1 ]
Kumthekar, Priya [1 ]
Macken, Micheal P. [1 ]
Schuele, Stephan U. [1 ]
Gerard, Elizabeth [1 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
关键词
auditory; hallucination; seizure; voltage-gated potassium channel antibody; LATERAL TEMPORAL EPILEPSY; AUTOSOMAL-DOMINANT; LGI1; ENCEPHALOPATHY; EXPERIENCE; MUTATIONS; LOBE;
D O I
10.1684/epd.2013.0623
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Limbic encephalitis involving anti-voltage-gated potassium channel antibodies (VGKC-LE) has become increasingly recognised, with seizures and psychotic features, such as hallucinations, being typical clinical manifestations. Though the literature supports auditory hallucinations as ictal phenomena, there are no reported cases of these hallucinations correlating with electrographic seizure for this disease entity. Early recognition of auditory hallucinations as seizures could alter treatment and subsequently affect short-term outcomes in these patients. We report the case of a patient with auditory hallucinations and progressive cognitive decline, as well as serological evidence of VGKC antibodies, in whom ictal hallucinations were identified by continuous video-EEG monitoring. This case highlights the subtlety of this entity, in both clinical and electrographic detection. [Published with video sequences]
引用
收藏
页码:433 / 436
页数:4
相关论文
共 15 条
[1]   Out-of-body experience and autoscopy of neurological origin [J].
Blanke, O ;
Landis, T ;
Spinelli, L ;
Seeck, M .
BRAIN, 2004, 127 :243-258
[2]   The significance of ear plugging in localization-related epilepsy [J].
Clarke, DF ;
Otsubo, H ;
Weiss, SK ;
Chitoku, S ;
Chuang, SH ;
Logan, WJ ;
Smith, TL ;
Elliot, I ;
Pang, EW ;
Rutka, JT ;
Snead, OC .
EPILEPSIA, 2003, 44 (12) :1562-1567
[3]   Paraneoplastic syndromes of the CNS [J].
Dalmau, Josep ;
Rosenfeld, Myrna R. .
LANCET NEUROLOGY, 2008, 7 (04) :327-340
[4]   Drug resistant ADLTE and recurrent partial status epilepticus with dysphasic features in a family with a novel LGI1 mutation: electroclinical, genetic, and EEG/fMRI findings [J].
Di Bonaventura, Carlo ;
Carni, Marco ;
Diani, Erica ;
Fattouch, Jinane ;
Vaudano, Elisabetta A. ;
Egeo, Gabriella ;
Pantano, Patrizia ;
Maraviglia, Bruno ;
Bozzao, Luigi ;
Manfredi, Mario ;
Prencipe, Massimiliano ;
Giallonardo, Teresa A. ;
Nobile, Carlo .
EPILEPSIA, 2009, 50 (11) :2481-2486
[5]   Delusions, illusions and hallucinations in epilepsy: 1. Elementary phenomena [J].
Elliott, Brent ;
Joyce, Eileen ;
Shorvon, Simon .
EPILEPSY RESEARCH, 2009, 85 (2-3) :162-171
[6]   Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia [J].
Irani, Sarosh R. ;
Alexander, Sian ;
Waters, Patrick ;
Kleopa, Kleopas A. ;
Pettingill, Philippa ;
Zuliani, Luigi ;
Peles, Elior ;
Buckley, Camilla ;
Lang, Bethan ;
Vincent, Angela .
BRAIN, 2010, 133 :2734-2748
[7]   Magnetic resonance imaging abnormalities in familial temporal lobe epilepsy with auditory auras [J].
Kobayashi, E ;
Santos, NF ;
Torres, FR ;
Secolin, R ;
Sardinha, LAC ;
Lopez-Cendes, I ;
Cendes, F .
ARCHIVES OF NEUROLOGY, 2003, 60 (11) :1546-1551
[8]   Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series [J].
Lai, Meizan ;
Huijbers, Maartje G. M. ;
Lancaster, Eric ;
Graus, Francesc ;
Bataller, Luis ;
Balice-Gordon, Rita ;
Cowell, John K. ;
Dalmau, Josep .
LANCET NEUROLOGY, 2010, 9 (08) :776-785
[9]   Management of Voltage-Gated Potassium Channel Antibody Disorders [J].
Merchut, Michael P. .
NEUROLOGIC CLINICS, 2010, 28 (04) :941-+
[10]   Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy [J].
Morante-Redolat, JM ;
Gorostidi-Pagola, A ;
Piquer-Sirerol, S ;
Sáenz, A ;
Poza, JJ ;
Galán, J ;
Gesk, S ;
Sarafidou, T ;
Mautner, VF ;
Binelli, S ;
Staub, E ;
Hinzmann, B ;
French, L ;
Prud'homme, JF ;
Passarelli, D ;
Scannapieco, P ;
Tassinari, CA ;
Avanzini, G ;
Martí-Massó, JF ;
Kluwe, L ;
Deloukas, P ;
Moschonas, NK ;
Michelucci, R ;
Siebert, R ;
Nobile, C ;
Pérez-Tur, J ;
de Munain, AL .
HUMAN MOLECULAR GENETICS, 2002, 11 (09) :1119-1127